PDF(Pubmed)
Abstract：
With the increasing proportion of the aging population, neurodegenerative diseases have become one of the major health issues in society. Neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer\'s disease (AD), Parkinson\'s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neurodegeneration associated with aging, leading to a gradual decline in cognitive, emotional, and motor functions in patients. The process of aging is a normal physiological process in human life and is accompanied by the aging of the immune system, which is known as immunosenescence. T-cells are an important part of the immune system, and their senescence is the main feature of immunosenescence. The appearance of senescent T-cells has been shown to potentially lead to chronic inflammation and tissue damage, with some studies indicating a direct link between T-cell senescence, inflammation, and neuronal damage. The role of these subsets with different functions in NDs is still under debate. A growing body of evidence suggests that in people with a ND, there is a prevalence of CD4+ T-cell subsets exhibiting characteristics that are linked to senescence. This underscores the significance of CD4+ T-cells in NDs. In this review, we summarize the classification and function of CD4+ T-cell subpopulations, the characteristics of CD4+ T-cell senescence, the potential roles of these cells in animal models and human studies of NDs, and therapeutic strategies targeting CD4+ T-cell senescence.
摘要：
随着人口老龄化比例的不断增加,神经退行性疾病已成为社会的主要健康问题之一。神经退行性疾病（ND），包括多发性硬化症（MS），阿尔茨海默病（AD），帕金森病（PD），和肌萎缩侧索硬化症（ALS），以与衰老相关的进行性神经变性为特征，导致认知逐渐下降，情感,和患者的运动功能。衰老过程是人类生命中正常的生理过程,伴随着免疫系统的衰老,这被称为免疫衰老。T细胞是免疫系统的重要组成部分,衰老是免疫衰老的主要特征。衰老T细胞的出现已被证明可能导致慢性炎症和组织损伤，一些研究表明T细胞衰老之间存在直接联系，炎症,和神经元损伤。这些具有不同功能的子集在ND中的作用仍在争论中。越来越多的证据表明，在患有ND的人中，CD4+T细胞亚群表现出与衰老相关的特征。这强调了CD4+T细胞在ND中的重要性。在这次审查中,我们总结了CD4+T细胞亚群的分类和功能，CD4+T细胞衰老的特点，这些细胞在动物模型和人类研究中的潜在作用，以及针对CD4+T细胞衰老的治疗策略。
