PDF(Pubmed)
Abstract：
ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their pivotal involvement in brain physiology and neurodegenerative disorders, such as Alzheimer\'s disease (AD). Glial cells are fundamental for normal CNS function and engage with several ABC transporters in different ways. Here, we specifically highlight ABC transporters involved in the maintenance of brain homeostasis and their implications in its metabolic regulation. We also show new aspects related to ABC transporter function found in less recognized diseases, such as Huntington\'s disease (HD) and experimental autoimmune encephalomyelitis (EAE), as a model for multiple sclerosis (MS). Understanding both their impact on the physiological regulation of the CNS and their roles in brain diseases holds promise for uncovering new therapeutic options. Further investigations and preclinical studies are warranted to elucidate the complex interplay between glial ABC transporters and physiological brain functions, potentially leading to effective therapeutic interventions also for rare CNS disorders.
摘要：
ATP结合盒（ABC）转运蛋白对于跨不同细胞膜的各种底物的流出起着至关重要的作用。在中枢神经系统（CNS），ABC转运蛋白最近由于其在脑生理学和神经退行性疾病中的关键参与而引起了极大的关注，如阿尔茨海默病（AD）。胶质细胞是正常CNS功能的基础，并以不同的方式与几种ABC转运蛋白结合。这里,我们特别强调了与维持脑稳态有关的ABC转运体及其在代谢调节中的意义.我们还显示了在较少识别的疾病中发现的与ABC转运蛋白功能相关的新方面，如亨廷顿病（HD）和实验性自身免疫性脑脊髓炎（EAE），作为多发性硬化症（MS）的模型。了解它们对中枢神经系统生理调节的影响以及它们在脑部疾病中的作用，有望发现新的治疗选择。进一步的研究和临床前研究是必要的，以阐明复杂的相互作用之间的神经胶质ABC转运蛋白和生理脑功能，可能导致对罕见中枢神经系统疾病的有效治疗干预。
