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Abstract：
BACKGROUND: Alcohol consumption by children and adolescents is receiving increasing attention. It may cause dyslipidemia, a risk factor for cardiovascular disease. However, the association between alcohol consumption and blood lipids in children and adolescents is unclear, and so we aimed to characterize this association.
METHODS: Data from the China Health and Nutrition Survey were extracted from children and adolescents aged 7-18 years for whom information was available on alcohol consumption. The population was divided into drinking and nondrinking groups. The χ2, Student\'s t, or Mann-Whitney U test was used to compare groups. Univariate and multivariate linear regression and propensity score matching (PSM) analysis were used to identify the association between alcohol consumption and blood lipids.
RESULTS: This study included 408 children and adolescents with 35 drinkers and 373 nondrinkers. The drinkers had significantly lower values of total cholesterol (TC) (3.8 mmol/L for nondrinkers versus 3.5 mmol/L for drinkers, p = 0.002) and high-density lipoprotein cholesterol (HDL-C) (1.3 mmol/L for nondrinkers versus 1.2 mmol/L for drinkers, p = 0.007), but not for low-density lipoprotein cholesterol (LDL-C) (2.1 mmol/L for nondrinkers versus 2.0 mmol/L for drinkers, p = 0.092) or triglyceride (TG) (0.9 mmol/L for nondrinkers versus 0.8 mmol/L for drinkers, p = 0.21). The univariate and multivariate analyses led to the same conclusions. After PSM there was still a significant negative association between alcohol consumption and TC or HDL-C.
CONCLUSIONS: Alcohol consumption in children and adolescents exhibited significant negative associated with TC and HDL-C, but not with LDL-C or TG. These findings need to be confirmed in future prospective research, and the health effects of blood lipid changes caused by drinking in children and adolescents need to be clarified.
METHODS: Data from the China Health and Nutrition Survey were extracted from children and adolescents aged 7-18 years for whom information was available on alcohol consumption. The population was divided into drinking and nondrinking groups. The χ2, Student\'s t, or Mann-Whitney U test was used to compare groups. Univariate and multivariate linear regression and propensity score matching (PSM) analysis were used to identify the association between alcohol consumption and blood lipids.
RESULTS: This study included 408 children and adolescents with 35 drinkers and 373 nondrinkers. The drinkers had significantly lower values of total cholesterol (TC) (3.8 mmol/L for nondrinkers versus 3.5 mmol/L for drinkers, p = 0.002) and high-density lipoprotein cholesterol (HDL-C) (1.3 mmol/L for nondrinkers versus 1.2 mmol/L for drinkers, p = 0.007), but not for low-density lipoprotein cholesterol (LDL-C) (2.1 mmol/L for nondrinkers versus 2.0 mmol/L for drinkers, p = 0.092) or triglyceride (TG) (0.9 mmol/L for nondrinkers versus 0.8 mmol/L for drinkers, p = 0.21). The univariate and multivariate analyses led to the same conclusions. After PSM there was still a significant negative association between alcohol consumption and TC or HDL-C.
CONCLUSIONS: Alcohol consumption in children and adolescents exhibited significant negative associated with TC and HDL-C, but not with LDL-C or TG. These findings need to be confirmed in future prospective research, and the health effects of blood lipid changes caused by drinking in children and adolescents need to be clarified.
摘要：
背景：儿童和青少年的饮酒受到越来越多的关注。它可能会导致血脂异常，心血管疾病的危险因素。然而,儿童和青少年饮酒与血脂之间的关系尚不清楚，所以我们旨在描述这种联系。
方法：来自中国健康与营养调查的数据来自7-18岁的儿童和青少年，他们有关于饮酒的信息。人口分为饮酒和不饮酒组。χ2，学生t，或Mann-WhitneyU检验用于比较组。使用单变量和多变量线性回归以及倾向评分匹配（PSM）分析来确定饮酒与血脂之间的关联。
结果：这项研究包括408名儿童和青少年，其中35名饮酒者和373名非饮酒者。饮酒者的总胆固醇（TC）值显着降低（非饮酒者为3.8mmol/L，饮酒者为3.5mmol/L，p=0.002）和高密度脂蛋白胆固醇（HDL-C）（非饮酒者为1.3mmol/L，饮酒者为1.2mmol/L，p=0.007),但不是低密度脂蛋白胆固醇（LDL-C）（不饮酒者为2.1mmol/L，饮酒者为2.0mmol/L，p=0.092）或甘油三酯（TG）（非饮酒者为0.9mmol/L，饮酒者为0.8mmol/L，p=0.21）。单变量和多变量分析得出了相同的结论。PSM后，饮酒与TC或HDL-C之间仍然存在显着负相关。
结论：儿童和青少年饮酒与TC和HDL-C呈显著负相关，但不是LDL-C或TG。这些发现需要在未来的前瞻性研究中得到证实，需要澄清儿童和青少年饮酒引起的血脂变化对健康的影响。
方法：来自中国健康与营养调查的数据来自7-18岁的儿童和青少年，他们有关于饮酒的信息。人口分为饮酒和不饮酒组。χ2，学生t，或Mann-WhitneyU检验用于比较组。使用单变量和多变量线性回归以及倾向评分匹配（PSM）分析来确定饮酒与血脂之间的关联。
结果：这项研究包括408名儿童和青少年，其中35名饮酒者和373名非饮酒者。饮酒者的总胆固醇（TC）值显着降低（非饮酒者为3.8mmol/L，饮酒者为3.5mmol/L，p=0.002）和高密度脂蛋白胆固醇（HDL-C）（非饮酒者为1.3mmol/L，饮酒者为1.2mmol/L，p=0.007),但不是低密度脂蛋白胆固醇（LDL-C）（不饮酒者为2.1mmol/L，饮酒者为2.0mmol/L，p=0.092）或甘油三酯（TG）（非饮酒者为0.9mmol/L，饮酒者为0.8mmol/L，p=0.21）。单变量和多变量分析得出了相同的结论。PSM后，饮酒与TC或HDL-C之间仍然存在显着负相关。
结论：儿童和青少年饮酒与TC和HDL-C呈显著负相关，但不是LDL-C或TG。这些发现需要在未来的前瞻性研究中得到证实，需要澄清儿童和青少年饮酒引起的血脂变化对健康的影响。
