METHODS: Data from the China Health and Nutrition Survey were extracted from children and adolescents aged 7-18 years for whom information was available on alcohol consumption. The population was divided into drinking and nondrinking groups. The χ2, Student\'s t, or Mann-Whitney U test was used to compare groups. Univariate and multivariate linear regression and propensity score matching (PSM) analysis were used to identify the association between alcohol consumption and blood lipids.
RESULTS: This study included 408 children and adolescents with 35 drinkers and 373 nondrinkers. The drinkers had significantly lower values of total cholesterol (TC) (3.8 mmol/L for nondrinkers versus 3.5 mmol/L for drinkers, p = 0.002) and high-density lipoprotein cholesterol (HDL-C) (1.3 mmol/L for nondrinkers versus 1.2 mmol/L for drinkers, p = 0.007), but not for low-density lipoprotein cholesterol (LDL-C) (2.1 mmol/L for nondrinkers versus 2.0 mmol/L for drinkers, p = 0.092) or triglyceride (TG) (0.9 mmol/L for nondrinkers versus 0.8 mmol/L for drinkers, p = 0.21). The univariate and multivariate analyses led to the same conclusions. After PSM there was still a significant negative association between alcohol consumption and TC or HDL-C.
CONCLUSIONS: Alcohol consumption in children and adolescents exhibited significant negative associated with TC and HDL-C, but not with LDL-C or TG. These findings need to be confirmed in future prospective research, and the health effects of blood lipid changes caused by drinking in children and adolescents need to be clarified.
方法:来自中国健康与营养调查的数据来自7-18岁的儿童和青少年,他们有关于饮酒的信息。人口分为饮酒和不饮酒组。χ2,学生t,或Mann-WhitneyU检验用于比较组。使用单变量和多变量线性回归以及倾向评分匹配(PSM)分析来确定饮酒与血脂之间的关联。
结果:这项研究包括408名儿童和青少年,其中35名饮酒者和373名非饮酒者。饮酒者的总胆固醇(TC)值显着降低(非饮酒者为3.8mmol/L,饮酒者为3.5mmol/L,p=0.002)和高密度脂蛋白胆固醇(HDL-C)(非饮酒者为1.3mmol/L,饮酒者为1.2mmol/L,p=0.007),但不是低密度脂蛋白胆固醇(LDL-C)(不饮酒者为2.1mmol/L,饮酒者为2.0mmol/L,p=0.092)或甘油三酯(TG)(非饮酒者为0.9mmol/L,饮酒者为0.8mmol/L,p=0.21)。单变量和多变量分析得出了相同的结论。PSM后,饮酒与TC或HDL-C之间仍然存在显着负相关。
结论:儿童和青少年饮酒与TC和HDL-C呈显著负相关,但不是LDL-C或TG。这些发现需要在未来的前瞻性研究中得到证实,需要澄清儿童和青少年饮酒引起的血脂变化对健康的影响。