Abstract：
Leukocyte elastase is a marker of inflammation. Previously, a relationship was found between the severity of mental disorders in patients and elastase-like activity of blood plasma. The effect of various neurotropic drugs on leukocyte elastase activity was analyzed in an in vitro experiment. We revealed an inhibitory effect of the benzodiazepine tranquilizers diazepam and bromodihydrochlorophenylbenzodiazepine and immunomodulators aminodihydrophthalazinedione and diclofenac on the plasma elastase-like activity of healthy donors and pure human neutrophil elastase. The antipsychotics chlorpromazine and alimemazine, as well as the nootropic vinpocetine increased elastase-like activity in a dose-dependent manner. The activating effect of chlorpromazine and vinpocetine, but not alimemazine, was reproduced in neutrophil elastase. We hypothesized that these drugs can affect the development of inflammatory reactions in the complex therapy of mental disorders.
摘要：
白细胞弹性蛋白酶是炎症的标志物。以前,发现患者精神障碍的严重程度与血浆弹性蛋白酶样活性有关.在体外实验中分析了各种亲神经药物对白细胞弹性蛋白酶活性的影响。我们揭示了苯并二氮卓类镇静剂地西泮和溴代氢氯苯基苯并二氮卓类和免疫调节剂氨基二氢噻嗪二酮和双氯芬酸对健康供体和纯人类中性粒细胞弹性蛋白酶的血浆弹性蛋白酶样活性的抑制作用。抗精神病药物氯丙嗪和阿利马嗪，以及促智药长春西汀以剂量依赖性方式增加弹性蛋白酶样活性。氯丙嗪和长春西汀的激活作用，但不是阿利马嗪，在中性粒细胞弹性蛋白酶中复制。我们假设这些药物可以在精神障碍的复杂治疗中影响炎症反应的发展。
