PDF(Pubmed)
Abstract：
This study investigated the potential associations between allergic diseases (asthma, allergic rhinitis, and atopic dermatitis) and the development of primary open-angle glaucoma. We utilized authorized data from the Korean National Health Information Database (KNHID), which provides comprehensive medical claims data and information from the National Health Screening Program. We compared the baseline characteristics of subjects with and without allergic diseases and calculated the incidence and risk of glaucoma development. Cox proportional hazard regression analysis was used to determine the risk of glaucoma development in subjects with allergic diseases. A total of 171,129 subjects aged 20-39 with or without allergic diseases who underwent a general health examination between 2009 and 2015 were included. Subjects with allergic diseases exhibited a higher incidence of glaucoma compared to the control group. The hazard ratio (HR) of glaucoma onset was 1.49 and 1.39 in subjects with at least one allergic disease before and after adjusting for potential confounding factors, respectively. Among allergic diseases, atopic dermatitis showed the highest risk for glaucoma development (aHR 1.73) after adjusting for confounders. Allergic rhinitis showed an increased risk for incident glaucoma after adjustment (aHR 1.38). Asthma showed the lowest but still increased risk for glaucoma (aHR 1.22). The associations were consistent in all subgroup analyses stratified by sex, smoking, drinking, exercise, diabetes, hypertension, dyslipidemia, or history of steroid. In conclusion, allergic diseases are associated with increased risk of glaucoma development. Among allergic diseases, atopic dermatitis showed the highest risk for glaucoma development followed by allergic rhinitis and asthma.
摘要：
这项研究调查了过敏性疾病(哮喘，过敏性鼻炎,和特应性皮炎）和原发性开角型青光眼的发展。我们利用韩国国家健康信息数据库（KNHID）的授权数据，提供全面的医疗索赔数据和国家健康筛查计划的信息。我们比较了有和没有过敏性疾病的受试者的基线特征，并计算了青光眼发展的发生率和风险。Cox比例风险回归分析用于确定患有过敏性疾病的受试者发生青光眼的风险。共有171,129名年龄在20-39岁之间有或没有过敏性疾病的受试者在2009年至2015年期间接受了一般健康检查。与对照组相比，患有过敏性疾病的受试者表现出更高的青光眼发生率。在调整潜在的混杂因素之前和之后，在患有至少一种过敏性疾病的受试者中，青光眼发作的风险比（HR）分别为1.49和1.39。分别。在过敏性疾病中，校正混杂因素后,特应性皮炎出现青光眼的风险最高(aHR1.73).变应性鼻炎显示调整后发生青光眼的风险增加(aHR1.38)。哮喘的青光眼风险最低，但仍增加（aHR1.22）。在按性别分层的所有亚组分析中，关联是一致的，吸烟,饮酒,锻炼,糖尿病,高血压,血脂异常,或有类固醇史.总之,过敏性疾病与青光眼发展的风险增加有关。在过敏性疾病中，特应性皮炎发生青光眼的风险最高，其次是过敏性鼻炎和哮喘。
