Abstract：
UNASSIGNED: Systemic inflammation is associated with poor functional outcomes. However, the effects of improved inflammation on functional indicators remain unclear. This study aimed to clarify the relationship between improvements in systemic inflammation and activities of daily living (ADL) in patients after stroke.
UNASSIGNED: This retrospective cohort study included patients post stroke with systemic inflammation upon admission. Systemic inflammation was defined as a modified Glasgow Prognostic Score (mGPS) score of 1-2. Improvement in systemic inflammation was defined as a reduction in mGPS score or blood C-reactive protein (CRP) levels during hospitalization. The primary outcomes were the motor items of the Functional Independence Measure (FIM-motor) at discharge. We applied multiple linear regression analysis to examine whether reduced systemic inflammation was associated with outcomes after adjusting for confounding factors.
UNASSIGNED: Of the 1490 patients recruited, 158 (median age, 79 years; 88 men) had systemic inflammation on admission and were included in the study. Among these patients, 131 (82.9%) and 147 (93.0%) exhibited reduced mGPS and CRP levels, respectively. The median change in CRP was 2.1 [1.1, 3.8] mg/dL. Multivariate analysis revealed that improvements in mGPS (β = 0.125, p = 0.012) and CRP levels (β = 0.108, p = 0.108) were independently and positively associated with FIM-motor at discharge.
UNASSIGNED: Improvement in systemic inflammation was positively associated with functional outcomes in patients post stroke. Early detection and therapeutic intervention for systemic inflammation may further improve outcomes in these patients.
UNASSIGNED: This retrospective cohort study included patients post stroke with systemic inflammation upon admission. Systemic inflammation was defined as a modified Glasgow Prognostic Score (mGPS) score of 1-2. Improvement in systemic inflammation was defined as a reduction in mGPS score or blood C-reactive protein (CRP) levels during hospitalization. The primary outcomes were the motor items of the Functional Independence Measure (FIM-motor) at discharge. We applied multiple linear regression analysis to examine whether reduced systemic inflammation was associated with outcomes after adjusting for confounding factors.
UNASSIGNED: Of the 1490 patients recruited, 158 (median age, 79 years; 88 men) had systemic inflammation on admission and were included in the study. Among these patients, 131 (82.9%) and 147 (93.0%) exhibited reduced mGPS and CRP levels, respectively. The median change in CRP was 2.1 [1.1, 3.8] mg/dL. Multivariate analysis revealed that improvements in mGPS (β = 0.125, p = 0.012) and CRP levels (β = 0.108, p = 0.108) were independently and positively associated with FIM-motor at discharge.
UNASSIGNED: Improvement in systemic inflammation was positively associated with functional outcomes in patients post stroke. Early detection and therapeutic intervention for systemic inflammation may further improve outcomes in these patients.
摘要：
■全身炎症与不良功能结局相关。然而,炎症改善对功能指标的影响尚不清楚.本研究旨在阐明卒中后患者全身炎症反应的改善与日常生活活动(ADL)之间的关系。
■这项回顾性队列研究纳入了入院时出现全身性炎症的卒中后患者。全身性炎症定义为1-2的改良格拉斯哥预后评分（mGPS）评分。全身性炎症的改善定义为住院期间mGPS评分或血液C反应蛋白（CRP）水平的降低。主要结果是出院时功能独立性测量（FIM-motor）的运动项目。我们应用多元线性回归分析，在校正混杂因素后，检查全身炎症反应减少是否与预后相关。
■在招募的1490名患者中，158（中位年龄，79岁；88名男性）入院时出现全身性炎症，并纳入研究。在这些患者中,131(82.9%)和147(93.0%)显示mGPS和CRP水平降低，分别。CRP变化中位数为2.1[1.1,3.8]mg/dL。多因素分析显示，mGPS（β=0.125，p=0.012）和CRP水平（β=0.108，p=0.108）的改善与出院时的FIM运动呈独立正相关。
■全身炎症的改善与卒中后患者的功能转归呈正相关。对全身性炎症的早期检测和治疗干预可以进一步改善这些患者的预后。
■这项回顾性队列研究纳入了入院时出现全身性炎症的卒中后患者。全身性炎症定义为1-2的改良格拉斯哥预后评分（mGPS）评分。全身性炎症的改善定义为住院期间mGPS评分或血液C反应蛋白（CRP）水平的降低。主要结果是出院时功能独立性测量（FIM-motor）的运动项目。我们应用多元线性回归分析，在校正混杂因素后，检查全身炎症反应减少是否与预后相关。
■在招募的1490名患者中，158（中位年龄，79岁；88名男性）入院时出现全身性炎症，并纳入研究。在这些患者中,131(82.9%)和147(93.0%)显示mGPS和CRP水平降低，分别。CRP变化中位数为2.1[1.1,3.8]mg/dL。多因素分析显示，mGPS（β=0.125，p=0.012）和CRP水平（β=0.108，p=0.108）的改善与出院时的FIM运动呈独立正相关。
■全身炎症的改善与卒中后患者的功能转归呈正相关。对全身性炎症的早期检测和治疗干预可以进一步改善这些患者的预后。
