Abstract：
There is rapidly growing awareness of microbiome assembly and function in early-life gut health. Although many factors, such as antibiotic use and highly processed diets, impinge on this process, most research has focused on people residing in high-income countries. However, much of the world\'s population lives in low- and middle-income countries (LMICs), where, in addition to erratic antibiotic use and suboptimal diets, these groups experience unique challenges. Indeed, many children in LMICs are infected with intestinal helminths. Although helminth infections are strongly associated with diverse developmental co-morbidities and induce profound microbiome changes, few studies have directly examined whether intersecting pathways between these components of the holobiont shape health outcomes in early life. Here, we summarize microbial colonization within the first years of human life, how helminth-mediated changes to the gut microbiome may affect postnatal growth, and why more research on this relationship may improve health across the lifespan.
摘要：
人们对早期肠道健康中的微生物组组装和功能的认识正在迅速增长。虽然有很多因素,如抗生素的使用和高度加工的饮食，影响这个过程，大多数研究都集中在居住在高收入国家的人身上。然而,世界上大部分人口生活在低收入和中等收入国家(LMICs)，where,除了不稳定的抗生素使用和欠佳的饮食，这些团体经历了独特的挑战。的确,LMIC中的许多儿童感染了肠道蠕虫。尽管蠕虫感染与多种发育合并症密切相关，并引起深刻的微生物组变化，很少有研究直接检查是否在生命早期的健康结局中，完整的这些组成部分之间的交叉途径。这里,我们总结了人类生命最初几年的微生物定植，蠕虫介导的肠道微生物组变化如何影响产后生长，以及为什么更多关于这种关系的研究可以改善整个生命周期的健康。
