Abstract：
Aim: To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances drug penetration and uptake in tumors. This aims to advance cancer treatment strategies. Materials & methods: We developed a multi-physics mathematical model to elucidate and understand the intricate mechanisms governing drug release, transport and delivery. Unique in vitro models (monolayer, multilayer, spheroid) and a tailored US exposure setup were introduced to evaluate drug penetration and uptake. Results: The results highlight the potential advantages of US-mediated NSDDSs over conventional NSDDSs and chemotherapy, notably in enhancing drug release and inducing cell death. Conclusion: Our sophisticated numerical and experimental methods aid in determining and quantifying drug penetration and uptake into solid tumors.
摘要：
目的：建立一种方法，以了解超声（US）如何诱导纳米尺寸药物递送系统（NSDDS）的药物释放并增强肿瘤中的药物渗透和吸收。这旨在推进癌症治疗策略。材料与方法：我们开发了一个多物理数学模型来阐明和理解药物释放的复杂机制，运输和交付。独特的体外模型(单层，多层,球体）和量身定制的美国暴露设置被引入以评估药物渗透和吸收。结果：结果突出了US介导的NSDDS相对于常规NSDDS和化疗的潜在优势，特别是在增强药物释放和诱导细胞死亡。结论：我们复杂的数值和实验方法有助于确定和量化药物在实体瘤中的渗透和摄取。
