Abstract：
The search for solutions to the vagaries of aging has, historically, been akin to searching at night in the bright light under street lamps by utilizing the few preexisting and well-established animal model systems. Throughout my career as a comparative biologist, I have ventured into the darkness across 4 continents and studied over 150 different animal species, many of which have evolved remarkable adaptations to survive on the harsh and rugged fitness landscape that exists outside of the laboratory setting. In this Fellows Forum, I will discuss the main focus of my research for the last 25 years and dig deeply into the biology of the preternaturally long-lived naked mole-rat that makes it an ideal model system for the characterization of successful strategies to combat aging.
摘要：
寻找变幻莫测的衰老解决方案，历史上,通过利用少数现有的和完善的动物模型系统，类似于夜间在路灯下的明亮光线下进行搜索。在我作为比较生物学家的整个职业生涯中，我冒险进入四大洲的黑暗，研究了150多种不同的动物，其中许多已经进化出了非凡的适应性，可以在实验室环境之外的严酷和崎岖的健身环境中生存。在这个研究员论坛上，我将讨论我过去25年研究的主要重点，并深入挖掘超自然长寿裸痣鼠的生物学，使其成为表征成功的抗衰老策略的理想模型系统。
