PDF(Pubmed)
Abstract：
UNASSIGNED: While it has been hypothesized that high plaque stress and strain may be related to plaque rupture, its direct verification using in vivo coronary plaque rupture data and full 3-dimensional fluid-structure interaction models is lacking in the current literature due to difficulty in obtaining in vivo plaque rupture imaging data from patients with acute coronary syndrome. This case-control study aims to use high-resolution optical coherence tomography-verified in vivo plaque rupture data and 3-dimensional fluid-structure interaction models to seek direct evidence for the high plaque stress/strain hypothesis.
UNASSIGNED: In vivo coronary plaque optical coherence tomography data (5 ruptured plaques, 5 no-rupture plaques) were acquired from patients using a protocol approved by the local institutional review board with informed consent obtained. The ruptured caps were reconstructed to their prerupture morphology using neighboring plaque cap and vessel geometries. Optical coherence tomography-based 3-dimensional fluid-structure interaction models were constructed to obtain plaque stress, strain, and flow shear stress data for comparative analysis. The rank-sum test in the nonparametric test was used for statistical analysis.
UNASSIGNED: Our results showed that the average maximum cap stress and strain values of ruptured plaques were 142% (457.70 versus 189.22 kPa; P=0.0278) and 48% (0.2267 versus 0.1527 kPa; P=0.0476) higher than that for no-rupture plaques, respectively. The mean values of maximum flow shear stresses for ruptured and no-rupture plaques were 145.02 dyn/cm2 and 81.92 dyn/cm2 (P=0.1111), respectively. However, the flow shear stress difference was not statistically significant.
UNASSIGNED: This preliminary case-control study showed that the ruptured plaque group had higher mean maximum stress and strain values. Due to our small study size, larger scale studies are needed to further validate our findings.
UNASSIGNED: In vivo coronary plaque optical coherence tomography data (5 ruptured plaques, 5 no-rupture plaques) were acquired from patients using a protocol approved by the local institutional review board with informed consent obtained. The ruptured caps were reconstructed to their prerupture morphology using neighboring plaque cap and vessel geometries. Optical coherence tomography-based 3-dimensional fluid-structure interaction models were constructed to obtain plaque stress, strain, and flow shear stress data for comparative analysis. The rank-sum test in the nonparametric test was used for statistical analysis.
UNASSIGNED: Our results showed that the average maximum cap stress and strain values of ruptured plaques were 142% (457.70 versus 189.22 kPa; P=0.0278) and 48% (0.2267 versus 0.1527 kPa; P=0.0476) higher than that for no-rupture plaques, respectively. The mean values of maximum flow shear stresses for ruptured and no-rupture plaques were 145.02 dyn/cm2 and 81.92 dyn/cm2 (P=0.1111), respectively. However, the flow shear stress difference was not statistically significant.
UNASSIGNED: This preliminary case-control study showed that the ruptured plaque group had higher mean maximum stress and strain values. Due to our small study size, larger scale studies are needed to further validate our findings.
摘要：
■虽然有人假设高斑块应力和应变可能与斑块破裂有关，目前文献中缺乏使用体内冠状动脉斑块破裂数据和完整的3维流体-结构相互作用模型对其进行直接验证,这是因为很难从急性冠状动脉综合征患者中获得体内斑块破裂成像数据.本病例对照研究旨在使用高分辨率光学相干断层扫描验证的体内斑块破裂数据和3维流体-结构相互作用模型来寻求高斑块应力/应变假说的直接证据。
■体内冠状动脉斑块光学相干断层扫描数据（5个破裂斑块，5个未破裂斑块）使用当地机构审查委员会批准的协议从患者获得知情同意。使用相邻的斑块盖和血管几何形状将破裂的盖重建为其破裂前的形态。构建基于光学相干层析成像的三维流体-结构相互作用模型,应变，和流动剪切应力数据进行比较分析。非参数检验中的秩和检验用于统计分析。
■我们的结果表明，破裂斑块的平均最大应力和应变值分别为142％（457.70对189.22kPa；P=0.0278）和48％（0.2267对0.1527kPa；P=0.0476）。分别。破裂和未破裂斑块的最大流动剪切应力的平均值分别为145.02dyn/cm2和81.92dyn/cm2（P=0.1111），分别。然而,流动剪切应力差异无统计学意义。
■这项初步病例对照研究表明，破裂斑块组的平均最大应力和应变值较高。由于我们的研究规模很小，需要更大规模的研究来进一步验证我们的发现.
■体内冠状动脉斑块光学相干断层扫描数据（5个破裂斑块，5个未破裂斑块）使用当地机构审查委员会批准的协议从患者获得知情同意。使用相邻的斑块盖和血管几何形状将破裂的盖重建为其破裂前的形态。构建基于光学相干层析成像的三维流体-结构相互作用模型,应变，和流动剪切应力数据进行比较分析。非参数检验中的秩和检验用于统计分析。
■我们的结果表明，破裂斑块的平均最大应力和应变值分别为142％（457.70对189.22kPa；P=0.0278）和48％（0.2267对0.1527kPa；P=0.0476）。分别。破裂和未破裂斑块的最大流动剪切应力的平均值分别为145.02dyn/cm2和81.92dyn/cm2（P=0.1111），分别。然而,流动剪切应力差异无统计学意义。
■这项初步病例对照研究表明，破裂斑块组的平均最大应力和应变值较高。由于我们的研究规模很小，需要更大规模的研究来进一步验证我们的发现.
