PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to evaluate oxidative stress parameters in individuals with depression and schizophrenia, considering gender differences, and manifesting suicidal behavior, encompassing thoughts without a tendency to be realized, thoughts with a tendency to be realized, and suicide attempts.
UNASSIGNED: From among the patients from Department of Psychiatry 120 individuals were selected who met the inclusion criteria and did not meet the exclusion criteria for the study. In the initial phase of the project, patients eligible for the study underwent the M.I.N.I 7.0.2 questionnaire (Mini International Neuropsychiatric Interview). Subsequently, in the second phase of the research, venous blood samples were collected from the patients for the purpose of conducting biochemical assessments, focusing on oxidative stress parameters.
UNASSIGNED: The obtained results suggest that redox biomarkers, namely TOS (total oxidation state) and OSI (TOS/TAC ratio), in the blood plasma of women increase in tandem with the severity of suicidal behavior. No notable alterations in SOD (Cu-Zn-superoxide dismutase), GPx (glutathione peroxidase), and GSH (reduced glutathione) concentrations and activity were noted between groups exhibiting suicidal behavior. The observed variations in the concentrations and activity of antioxidant parameters were significant solely in comparison to the control group.
UNASSIGNED: Redox biomarkers TOS and OSI could prove valuable in diagnosing women at a genuine risk of committing suicide. On the other hand, antioxidant parameters - SOD, GPx, and GSH may be instrumental in identifying patients with suicidal behaviors, without specifying their intensity.
UNASSIGNED: From among the patients from Department of Psychiatry 120 individuals were selected who met the inclusion criteria and did not meet the exclusion criteria for the study. In the initial phase of the project, patients eligible for the study underwent the M.I.N.I 7.0.2 questionnaire (Mini International Neuropsychiatric Interview). Subsequently, in the second phase of the research, venous blood samples were collected from the patients for the purpose of conducting biochemical assessments, focusing on oxidative stress parameters.
UNASSIGNED: The obtained results suggest that redox biomarkers, namely TOS (total oxidation state) and OSI (TOS/TAC ratio), in the blood plasma of women increase in tandem with the severity of suicidal behavior. No notable alterations in SOD (Cu-Zn-superoxide dismutase), GPx (glutathione peroxidase), and GSH (reduced glutathione) concentrations and activity were noted between groups exhibiting suicidal behavior. The observed variations in the concentrations and activity of antioxidant parameters were significant solely in comparison to the control group.
UNASSIGNED: Redox biomarkers TOS and OSI could prove valuable in diagnosing women at a genuine risk of committing suicide. On the other hand, antioxidant parameters - SOD, GPx, and GSH may be instrumental in identifying patients with suicidal behaviors, without specifying their intensity.
摘要：
■这项研究旨在评估抑郁症和精神分裂症患者的氧化应激参数，考虑到性别差异，表现出自杀行为，包含思想而没有实现的倾向，具有实现趋势的思想，和自杀企图。
■从精神科患者中选择120名符合纳入标准且不符合本研究排除标准的个体。在项目的初始阶段，符合研究条件的患者接受了M.I.N.I7.0.2问卷(迷你国际神经精神病学访谈).随后，在研究的第二阶段，为了进行生化评估，从患者身上采集静脉血样本，关注氧化应激参数。
■获得的结果表明，氧化还原生物标志物，即TOS(总氧化态)和OSI(TOS/TAC比)，在女性的血浆中，随着自杀行为的严重程度而增加。SOD（Cu-Zn-超氧化物歧化酶）无明显变化，GPx（谷胱甘肽过氧化物酶），和GSH（还原型谷胱甘肽）浓度和活性在表现出自杀行为的组之间被记录。与对照组相比，观察到的抗氧化剂参数的浓度和活性变化仅是显着的。
■氧化还原生物标志物TOS和OSI在诊断真正有自杀风险的女性方面可能被证明是有价值的。另一方面,抗氧化参数-SOD，GPx,GSH可能有助于识别有自杀行为的患者，没有说明他们的强度。
■从精神科患者中选择120名符合纳入标准且不符合本研究排除标准的个体。在项目的初始阶段，符合研究条件的患者接受了M.I.N.I7.0.2问卷(迷你国际神经精神病学访谈).随后，在研究的第二阶段，为了进行生化评估，从患者身上采集静脉血样本，关注氧化应激参数。
■获得的结果表明，氧化还原生物标志物，即TOS(总氧化态)和OSI(TOS/TAC比)，在女性的血浆中，随着自杀行为的严重程度而增加。SOD（Cu-Zn-超氧化物歧化酶）无明显变化，GPx（谷胱甘肽过氧化物酶），和GSH（还原型谷胱甘肽）浓度和活性在表现出自杀行为的组之间被记录。与对照组相比，观察到的抗氧化剂参数的浓度和活性变化仅是显着的。
■氧化还原生物标志物TOS和OSI在诊断真正有自杀风险的女性方面可能被证明是有价值的。另一方面,抗氧化参数-SOD，GPx,GSH可能有助于识别有自杀行为的患者，没有说明他们的强度。
