METHODS: We performed PRP treatment on 14 patients with AGA, observed their clinical efficacy, and collected scalp swab samples before and after treatment. The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.
RESULTS: The results showed that PRP was effective in the treatment of AGA patients, and the hair growth increased significantly. The results of relative abundance analysis of microbiota showed that after treatment, g_Cutibacterium increased and g_Staphylococcus decreased, which played a stable role in scalp microbiota. In addition, g_Lawsonella decreased, indicating that the scalp oil production decreased after treatment.
CONCLUSIONS: The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.
方法:我们对14例AGA患者进行了PRP治疗,观察其临床疗效,并收集治疗前后的头皮拭子样本。通过扩增16sRNA基因的V3-V4区域并测序进行细菌鉴定,对AGA患者治疗前后的头皮微生物区系进行表征。
结果:结果显示PRP治疗AGA患者有效,头发生长显著增加。微生物群相对丰度分析结果表明,g_葡萄球菌增加,g_葡萄球菌减少,在头皮微生物群中发挥了稳定的作用。此外,g_Lawsonella下降,表明治疗后头皮油产量下降。
结论:研究结果表明,PRP可能通过头皮微生物组重新平衡在治疗AGA中发挥作用。