PDF(Pubmed)
Abstract：
BACKGROUND: Androgenic alopecia (AGA) is the most common type of hair loss in men, and there are many studies on the treatment of hair loss by platelet-rich plasma (PRP). The human scalp contains a huge microbiome, but its role in the process of hair loss remains unclear, and the relationship between PRP and the microbiome needs further study. Therefore, the purpose of this study was to investigate the effect of PRP treatment on scalp microbiota composition.
METHODS: We performed PRP treatment on 14 patients with AGA, observed their clinical efficacy, and collected scalp swab samples before and after treatment. The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.
RESULTS: The results showed that PRP was effective in the treatment of AGA patients, and the hair growth increased significantly. The results of relative abundance analysis of microbiota showed that after treatment, g_Cutibacterium increased and g_Staphylococcus decreased, which played a stable role in scalp microbiota. In addition, g_Lawsonella decreased, indicating that the scalp oil production decreased after treatment.
CONCLUSIONS: The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.
METHODS: We performed PRP treatment on 14 patients with AGA, observed their clinical efficacy, and collected scalp swab samples before and after treatment. The scalp microflora of AGA patients before and after treatment was characterized by amplifying the V3-V4 region of the 16 s RNA gene and sequencing for bacterial identification.
RESULTS: The results showed that PRP was effective in the treatment of AGA patients, and the hair growth increased significantly. The results of relative abundance analysis of microbiota showed that after treatment, g_Cutibacterium increased and g_Staphylococcus decreased, which played a stable role in scalp microbiota. In addition, g_Lawsonella decreased, indicating that the scalp oil production decreased after treatment.
CONCLUSIONS: The findings suggest that PRP may play a role in treating AGA through scalp microbiome rebalancing.
摘要：
背景：雄激素性脱发（AGA）是男性最常见的脱发类型，富血小板血浆(PRP)治疗脱发的研究较多。人类的头皮含有巨大的微生物组，但其在脱发过程中的作用尚不清楚，PRP与微生物组的关系有待进一步研究。因此,这项研究的目的是研究PRP治疗对头皮微生物群组成的影响。
方法：我们对14例AGA患者进行了PRP治疗，观察其临床疗效,并收集治疗前后的头皮拭子样本。通过扩增16sRNA基因的V3-V4区域并测序进行细菌鉴定，对AGA患者治疗前后的头皮微生物区系进行表征。
结果:结果显示PRP治疗AGA患者有效,头发生长显著增加。微生物群相对丰度分析结果表明,g_葡萄球菌增加，g_葡萄球菌减少，在头皮微生物群中发挥了稳定的作用。此外,g_Lawsonella下降，表明治疗后头皮油产量下降。
结论：研究结果表明，PRP可能通过头皮微生物组重新平衡在治疗AGA中发挥作用。
方法：我们对14例AGA患者进行了PRP治疗，观察其临床疗效,并收集治疗前后的头皮拭子样本。通过扩增16sRNA基因的V3-V4区域并测序进行细菌鉴定，对AGA患者治疗前后的头皮微生物区系进行表征。
结果:结果显示PRP治疗AGA患者有效,头发生长显著增加。微生物群相对丰度分析结果表明,g_葡萄球菌增加，g_葡萄球菌减少，在头皮微生物群中发挥了稳定的作用。此外,g_Lawsonella下降，表明治疗后头皮油产量下降。
结论：研究结果表明，PRP可能通过头皮微生物组重新平衡在治疗AGA中发挥作用。
