Abstract：
Skin architecture and its underlying vascular structure could be used to assess the health status of skin. A non-invasive, high resolution and deep imaging modality able to visualize skin subcutaneous layers and vasculature structures could be useful for determining and characterizing skin disease and trauma. In this study, a multispectral high-frequency, linear array-based photoacoustic/ultrasound (PAUS) probe is developed and implemented for the imaging of rat skin in vivo. The study seeks to demonstrate the probe capabilities for visualizing the skin and its underlying structures, and for monitoring changes in skin structure and composition during a 5-day course of a chemical burn. We analayze composition of lipids, water, oxy-hemoglobin, and deoxy-hemoglobin (for determination of oxygen saturation) in the skin tissue. The study successfully demonstrated the high-frequency PAUS imaging probe was able to provide 3D images of the rat skin architecture, underlying vasculature structures, and oxygen saturation, water, lipids and total hemoglobin.
摘要：
皮肤结构及其潜在的血管结构可用于评估皮肤的健康状况。非侵入性，能够可视化皮肤皮下层和脉管系统结构的高分辨率和深度成像模式可用于确定和表征皮肤病和创伤。在这项研究中,多光谱高频，开发并实现了基于线性阵列的光声/超声（PAUS）探针，用于体内大鼠皮肤成像。该研究旨在证明探针可视化皮肤及其底层结构的能力，以及在5天的化学烧伤过程中监测皮肤结构和成分的变化。我们分析脂质的组成，水,氧合血红蛋白,和皮肤组织中的脱氧血红蛋白（用于测定氧饱和度）。该研究成功证明了高频PAUS成像探头能够提供大鼠皮肤结构的3D图像，潜在的脉管结构，和氧饱和度,水,脂质和总血红蛋白。
