SCAP - SREBP - 1 信号的 STAT3 激活上调脂肪酸合成以促进肿瘤生长。
关键词: FASN SCAP SCD1 SREBP-1 STAT3 fatty acid glioblastoma lipogenesis phospholipid
Mesh : STAT3 Transcription Factor / metabolism genetics Humans Sterol Regulatory Element Binding Protein 1 / metabolism genetics Membrane Proteins / metabolism genetics Fatty Acids / metabolism biosynthesis Signal Transduction Intracellular Signaling Peptides and Proteins / metabolism genetics Gene Expression Regulation, Neoplastic Cell Line, Tumor Stearoyl-CoA Desaturase / metabolism genetics Animals Glioblastoma / metabolism pathology genetics Up-Regulation Mice
来 源:
DOI:10.1016/j.jbc.2024.107351
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