Abstract：
Ornithologic study skins are specimens of avian skins that have been preserved by drying after removing the viscera and muscle. Because of the high value of study skins for scientific studies, specimens are shared among researchers. There is concern that study skins might be contaminated with high-consequence diseases such as highly pathogenic avian influenza virus (HPAIV) or Newcastle disease virus (NDV). To mitigate risk, thermal or chemical treatment of study skins may be required before transfer; however, such treatments might damage the specimens. Therefore, a study was conducted to evaluate the duration of infectivity of HPAIV and NDV in study skins prepared from infected chickens (Gallus gallus). Study skins were prepared from 10 chickens infected with each virus. Skin and feather pulp samples were taken at the time of study skin preparation to establish starting titers. Mean starting titers in the skin was 4.2 log10 and 5.1 log10 50% egg infectious doses (EID50) for HPAIV and NDV groups respectively, and were 6.7 log10 EID50 for HPAIV, and 6.4 log10 EID50 for NDV in feather pulp. Samples were collected at 2 and 4 wk of drying to quantify viable virus. At 2 wk, fewer samples had detectable virus and mean titers were 1.8 log10 (skin) and 2.1 log10 (feathers) EID50 for HPAIV, and 1.7 log10 (skin) and 3.5 log10 (feathers) EID50 for NDV. At 4 wk viable virus could not be detected in either tissue type.
摘要：
鸟类学研究皮肤是禽类皮肤的标本，在去除内脏和肌肉后通过干燥保存。因为研究皮肤对科学研究的价值很高，标本在研究人员之间共享。人们担心研究皮肤可能被高致病性禽流感病毒（HPAIV）或新城疫病毒（NDV）等高后果疾病污染。为了降低风险，转移前可能需要对研究皮肤进行热处理或化学处理；然而，这种治疗可能会损坏标本。因此,进行了一项研究，以评估从感染的鸡（鸡）制备的研究皮肤中HPAIV和NDV的感染性持续时间。从每种病毒感染的10只鸡制备研究皮肤。在研究皮肤制备时采集皮肤和羽毛浆样品以建立起始滴度。HPAIV和NDV组的皮肤平均起始滴度分别为4.2log10和5.1log1050％卵感染剂量（EID50），HPAIV的EID50为6.7log10，羽毛浆中NDV的EID50为6.4log10。在干燥2和4周收集样品以定量活病毒。在2周，HPAIV的可检测病毒样本较少，平均滴度为1.8log10（皮肤）和2.1log10（羽毛）EID50，NDV的EID50为1.7log10（皮肤）和3.5log10（羽毛）。在4周时，在两种组织类型中均未检测到活病毒。
