Abstract：
UNASSIGNED: This study aimed to investigate the potential correlation between the single-nucleotide polymorphism (SNP) of maternally expressed gene 3 (MEG3) and the clinical manifestations of diabetic retinopathy (DR).
UNASSIGNED: Five loci of MEG3 SNPs including rs4081134 (G/A), rs10144253 (T/C), rs7158663 (G/A), rs3087918 (T/G) and rs11160608 (A/C) were genotyped by TaqMan allelic discrimination in 457 non-DR patients and 280 DR individuals.
UNASSIGNED: The distribution frequency of MEG3 SNP rs7158663 GA (AOR: 0.683, 95% CI: 0.478-0.975, p = 0.036) and MEG3 SNP rs7158663 GA + AA (AOR: 0.686, 95% CI: 0.487-0.968, p = 0.032) were significantly lower in the DR group. And the MEG3 SNP rs7158663 GA + AA (AOR: 0.610, 95% CI: 0.377-0.985, p = 0.043) demonstrated a significantly lower distribution frequency in the male DR group. Besides, the DR patients with MEG3 SNP rs7158663 GA + AA genotype showed a significantly lower HbA1c level than the DR patients with MEG3 SNP rs7158663 GG genotype (7.29 ± 1.23 versus 7.74 ± 1.49, p = 0.013). Moreover, in the analysis using data from gene expression data series database, a higher MEG3 level was significantly correlated to a lower miR-182 level in the database (p = 0.0114).
UNASSIGNED: In this study, the distribution frequency of MEG3 SNP rs7158663 GA + AA genotype was lower in DR, while the DR would develop under lower HbA1c level in DM patients with this MEG3 SNP variant.
UNASSIGNED: Five loci of MEG3 SNPs including rs4081134 (G/A), rs10144253 (T/C), rs7158663 (G/A), rs3087918 (T/G) and rs11160608 (A/C) were genotyped by TaqMan allelic discrimination in 457 non-DR patients and 280 DR individuals.
UNASSIGNED: The distribution frequency of MEG3 SNP rs7158663 GA (AOR: 0.683, 95% CI: 0.478-0.975, p = 0.036) and MEG3 SNP rs7158663 GA + AA (AOR: 0.686, 95% CI: 0.487-0.968, p = 0.032) were significantly lower in the DR group. And the MEG3 SNP rs7158663 GA + AA (AOR: 0.610, 95% CI: 0.377-0.985, p = 0.043) demonstrated a significantly lower distribution frequency in the male DR group. Besides, the DR patients with MEG3 SNP rs7158663 GA + AA genotype showed a significantly lower HbA1c level than the DR patients with MEG3 SNP rs7158663 GG genotype (7.29 ± 1.23 versus 7.74 ± 1.49, p = 0.013). Moreover, in the analysis using data from gene expression data series database, a higher MEG3 level was significantly correlated to a lower miR-182 level in the database (p = 0.0114).
UNASSIGNED: In this study, the distribution frequency of MEG3 SNP rs7158663 GA + AA genotype was lower in DR, while the DR would develop under lower HbA1c level in DM patients with this MEG3 SNP variant.
摘要：
■本研究旨在探讨母体表达基因3（MEG3）的单核苷酸多态性（SNP）与糖尿病视网膜病变（DR）临床表现之间的潜在相关性。
■MEG3SNP的五个基因座，包括rs4081134（G/A），rs10144253(T/C),rs7158663(G/A),rs3087918(T/G)和rs11160608(A/C)在457例非DR患者和280例DR个体中通过TaqMan等位基因区分进行基因分型。
■DR组MEG3SNPrs7158663GA(AOR:0.683,95%CI:0.478-0.975,p=0.036)和MEG3SNPrs7158663GA+AA(AOR:0.686,95%CI:0.487-0.968,p=0.032)的分布频率明显低于DR组。并且MEG3SNPrs7158663GAAA（AOR：0.610，95％CI：0.377-0.985，p=0.043）在男性DR组中显示出明显较低的分布频率。此外,MEG3SNPrs7158663GA+AA基因型的DR患者HbA1c水平显著低于MEG3SNPrs7158663GG基因型的DR患者(7.29±1.23对7.74±1.49,p=0.013).此外，在使用基因表达数据系列数据库的数据分析中，在数据库中,较高的MEG3水平与较低的miR-182水平显著相关(p=0.0114).
■在这项研究中，MEG3SNPrs7158663GA+AA基因型在DR中的分布频率较低，而在患有MEG3SNP变异的DM患者中，DR会在较低的HbA1c水平下发展。
■MEG3SNP的五个基因座，包括rs4081134（G/A），rs10144253(T/C),rs7158663(G/A),rs3087918(T/G)和rs11160608(A/C)在457例非DR患者和280例DR个体中通过TaqMan等位基因区分进行基因分型。
■DR组MEG3SNPrs7158663GA(AOR:0.683,95%CI:0.478-0.975,p=0.036)和MEG3SNPrs7158663GA+AA(AOR:0.686,95%CI:0.487-0.968,p=0.032)的分布频率明显低于DR组。并且MEG3SNPrs7158663GAAA（AOR：0.610，95％CI：0.377-0.985，p=0.043）在男性DR组中显示出明显较低的分布频率。此外,MEG3SNPrs7158663GA+AA基因型的DR患者HbA1c水平显著低于MEG3SNPrs7158663GG基因型的DR患者(7.29±1.23对7.74±1.49,p=0.013).此外，在使用基因表达数据系列数据库的数据分析中，在数据库中,较高的MEG3水平与较低的miR-182水平显著相关(p=0.0114).
■在这项研究中，MEG3SNPrs7158663GA+AA基因型在DR中的分布频率较低，而在患有MEG3SNP变异的DM患者中，DR会在较低的HbA1c水平下发展。
