关键词: Antitumor Effect Review Traditional Chinese Medicine (TCM) Tumor Characteristics

Mesh : Humans Neoplasms / drug therapy genetics Medicine, Chinese Traditional Apoptosis / drug effects Drugs, Chinese Herbal / therapeutic use pharmacology Neovascularization, Pathologic / drug therapy Cell Proliferation / drug effects Phytotherapy Genomic Instability Energy Metabolism / drug effects

来  源:   DOI:10.1142/S0192415X24500253

Abstract:
In recent years, due to advancements in medical conditions and the development of scientific research, the fundamental research of TCM antitumor treatments has progressed from the cellular level to the molecular and genetic levels. Previous studies have demonstrated the significant role of traditional Chinese medicine (TCM) in antitumor therapy through various mechanisms and pathways. Its mechanism of action is closely associated with cancer biology across different stages. This includes inhibiting tumor cell proliferation, blocking invasion and metastasis to surrounding tissues, inducing tumor cell apoptosis, inhibiting tumor angiogenesis, regulating immune function, maintaining genome stability, preventing mutation, and regulating cell energy metabolism. The use of TCM for eliciting antitumor effects not only has a good therapeutic effect and low side effects, it also provides a solid theoretical basis for clinical treatment and medication. This paper reviews the mechanism of the antitumor effects of TCM based on tumor characteristics. Through our review, we found that TCM not only directly inhibits tumors, but also enhances the body\'s immunity, thereby indirectly inducing an antitumor effect. This function aligns with the TCM theory of \"strengthening the body\'s resistance to eliminate pathogenic factors\". Furthermore, TCM will play a significant role in tumor treatment in clinical settings.
摘要:
近年来,由于医疗条件的进步和科学研究的发展,中医药抗肿瘤治疗的基础研究已经从细胞水平发展到分子和基因水平。以往的研究已经证明了中药通过多种机制和途径在抗肿瘤治疗中的重要作用。其作用机制与不同阶段的癌症生物学密切相关。这包括抑制肿瘤细胞增殖,阻断对周围组织的侵袭和转移,诱导肿瘤细胞凋亡,抑制肿瘤血管生成,调节免疫功能,保持基因组稳定性,防止突变,调节细胞能量代谢。用中药引致抗肿瘤作用,不仅疗效好,副作用低,为临床治疗和用药提供了坚实的理论依据。本文从肿瘤特点出发,对中药抗肿瘤作用的机制进行综述。通过我们的审查,我们发现中药不仅直接抑制肿瘤,还能增强人体的免疫力,从而间接诱导抗肿瘤作用。这一功能符合中医“增强机体抵抗力以消除致病因素”的理论。此外,中医药在肿瘤临床治疗中将发挥重要作用。
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