Abstract：
Cytokines from the Tumour Necrosis Factor (TNF) family are important regulators of both physiological and pathological processes. The discovery of novel TNF ligands and receptors, BAFF and APRIL, have opened up new possibilities for scientists to explore the effect of these cytokines on the human immune system. The role of BAFF/APRIL system in B lymphocytes is particularly important for survival and maintenance of homeostasis. Aberrant expression of the system is associated with various immunological disorders. Hence, this study provides a comprehensive overview of the past and present BAFF/APRIL system research development in a bibliometric perspective. To our best knowledge, this is the first ever bibliometric analysis conducted focusing on the BAFF/APRIL system. A total of 1055 relevant documents were retrieved from WoSCC. Microsoft Excel, VOSviewer, and Biblioshiny of R studio were bibliometric tools used to analyse the scientific literature. From 1999, the annual publications showed an upward trend, with Journal of Immunology being the most productive journal. USA leads the race for BAFF/APRIL system research developments. Pascal Schneider, a senior researcher affiliated with University of Lausanne, Switzerland was recognised as the most productive author and institution in the BAFF/APRIL system research field. The research focus transitioned from focusing on the role of the system in B cell biology, to immunological disorders and finally to development of BAFF/APRIL targeting drugs. Despite several studies elucidating briefly the pathway mechanism of BAFF/APRIL system in B-cell selection, substantial research on the mechanism of action in disease models and T cell activation and development of immunomodulating drugs from natural origins remains largely unexplored. Therefore, future research focusing on these areas are crucial for the deeper understanding of the system in disease manifestations and progression allowing a better treatment management for various immunological disorders.
摘要：
来自肿瘤坏死因子(TNF)家族的细胞因子是生理和病理过程的重要调节因子。新的TNF配体和受体的发现，BAFF和4月,为科学家探索这些细胞因子对人体免疫系统的影响开辟了新的可能性。BAFF/APRIL系统在B淋巴细胞中的作用对于生存和维持稳态尤为重要。该系统的异常表达与各种免疫疾病有关。因此，本研究从文献计量学的角度全面概述了过去和现在的BAFF/APRIL系统的研究进展。据我们所知，这是首次针对BAFF/APRIL系统进行的文献计量分析。从WoSCC共检索到1055个相关文档。MicrosoftExcel,VOSviewer,R工作室的Biblioshiny是用于分析科学文献的文献计量工具。从1999年开始，年度出版物呈上升趋势，《免疫学杂志》是最有成效的杂志。美国在BAFF/APRIL系统研究开发方面处于领先地位。PascalSchneider,洛桑大学的高级研究员，瑞士被认为是BAFF/APRIL系统研究领域最有生产力的作者和机构。研究重点从专注于系统在B细胞生物学中的作用转变。免疫疾病，最后是BAFF/APRIL靶向药物的开发。尽管一些研究简要阐明了BAFF/APRIL系统在B细胞选择中的通路机制,关于疾病模型和T细胞活化的作用机制的大量研究以及来自天然来源的免疫调节药物的开发仍未被探索。因此,针对这些领域的未来研究对于更深入地了解疾病表现和进展的系统至关重要，从而可以更好地治疗各种免疫疾病。
