Abstract：
OBJECTIVE: To evaluate the levels of anxiety and depression in patients with symptomatic vitreous floaters and to determine the possible correlations of psychological implications with the symptoms duration and possible improvement, the degree of posterior vitreous detachment, and the discomfort severity.
METHODS: Ninety patients complaining for floaters and fifty-seven age- and gender-matched healthy-control subjects were recruited. Every participant underwent a complete ophthalmological examination, including funduscopy and optical coherence tomography scans, while clinical and demographic data were also gathered. The Patient Health Questionnaire-9 (PHQ-9), the Zung Depression Inventory-Self-Rating Depression Scale (Zung SDS), and the Hospital Anxiety and Depression Scale (HADS) were completed by everyone.
RESULTS: Between the studied groups, no significant differences were detected regarding the clinical and demographic data (p > 0.05). The patients with floaters had significantly higher scores of PHQ-9, Zung SDS, HADS Anxiety, and HADS Depression (p < 0.001). After adjustment for several confounders, PHQ-9 (p = 0.041), Zung SDS (p = 0.003), and HADS Anxiety (p = 0.036) values remained significantly impaired. Among the patients, PHQ-9 and Zung SDS scores were significantly elevated in the patients with floaters duration less than 4 weeks (p < 0.05). Finally, anxiety and depression were significantly correlated with the symptoms duration and intensity, with the floater-associated discomfort, and with the stage of posterior vitreous detachment.
CONCLUSIONS: Vitreous floaters have a negative impact on patients\' psychological status, by the terms of enhanced depressive and anxiety levels. To the best of our knowledge, our study is the first in the literature to elaborate the aforementioned association, by assessing three different questionnaires simultaneously.
METHODS: Ninety patients complaining for floaters and fifty-seven age- and gender-matched healthy-control subjects were recruited. Every participant underwent a complete ophthalmological examination, including funduscopy and optical coherence tomography scans, while clinical and demographic data were also gathered. The Patient Health Questionnaire-9 (PHQ-9), the Zung Depression Inventory-Self-Rating Depression Scale (Zung SDS), and the Hospital Anxiety and Depression Scale (HADS) were completed by everyone.
RESULTS: Between the studied groups, no significant differences were detected regarding the clinical and demographic data (p > 0.05). The patients with floaters had significantly higher scores of PHQ-9, Zung SDS, HADS Anxiety, and HADS Depression (p < 0.001). After adjustment for several confounders, PHQ-9 (p = 0.041), Zung SDS (p = 0.003), and HADS Anxiety (p = 0.036) values remained significantly impaired. Among the patients, PHQ-9 and Zung SDS scores were significantly elevated in the patients with floaters duration less than 4 weeks (p < 0.05). Finally, anxiety and depression were significantly correlated with the symptoms duration and intensity, with the floater-associated discomfort, and with the stage of posterior vitreous detachment.
CONCLUSIONS: Vitreous floaters have a negative impact on patients\' psychological status, by the terms of enhanced depressive and anxiety levels. To the best of our knowledge, our study is the first in the literature to elaborate the aforementioned association, by assessing three different questionnaires simultaneously.
摘要：
目的：评估有症状的玻璃体漂浮物患者的焦虑和抑郁水平，并确定心理暗示与症状持续时间和可能的改善之间的可能相关性。玻璃体后脱离的程度,和不适的严重程度。
方法：招募了90名抱怨漂浮物的患者和57名年龄和性别匹配的健康对照受试者。每个参与者都接受了完整的眼科检查，包括眼底镜检查和光学相干断层扫描，同时还收集了临床和人口统计数据。患者健康问卷-9（PHQ-9），Zung抑郁量表-抑郁自评量表(ZungSDS)，医院焦虑和抑郁量表（HADS）由每个人完成。
结果：在研究组之间，在临床和人口统计学数据方面没有发现显着差异（p>0.05）。有漂浮物的患者有显著较高的PHQ-9，ZungSDS，HADS焦虑,和HADS抑郁（p<0.001）。在调整了几个混杂因素后，PHQ-9（p=0.041），ZungSDS（p=0.003），和HADS焦虑(p=0.036)值仍然显著受损。在患者中,PHQ-9和ZungSDS评分在漂浮物持续时间少于4周的患者中显著升高(p<0.05)。最后,焦虑和抑郁与症状持续时间和强度显著相关，与浮子相关的不适，以及玻璃体后脱离的阶段。
结论：玻璃体漂浮物对患者的心理状态有负面影响，通过增强的抑郁和焦虑水平。据我们所知,我们的研究是文献中第一个阐述上述关联的研究，通过同时评估三个不同的问卷。
方法：招募了90名抱怨漂浮物的患者和57名年龄和性别匹配的健康对照受试者。每个参与者都接受了完整的眼科检查，包括眼底镜检查和光学相干断层扫描，同时还收集了临床和人口统计数据。患者健康问卷-9（PHQ-9），Zung抑郁量表-抑郁自评量表(ZungSDS)，医院焦虑和抑郁量表（HADS）由每个人完成。
结果：在研究组之间，在临床和人口统计学数据方面没有发现显着差异（p>0.05）。有漂浮物的患者有显著较高的PHQ-9，ZungSDS，HADS焦虑,和HADS抑郁（p<0.001）。在调整了几个混杂因素后，PHQ-9（p=0.041），ZungSDS（p=0.003），和HADS焦虑(p=0.036)值仍然显著受损。在患者中,PHQ-9和ZungSDS评分在漂浮物持续时间少于4周的患者中显著升高(p<0.05)。最后,焦虑和抑郁与症状持续时间和强度显著相关，与浮子相关的不适，以及玻璃体后脱离的阶段。
结论：玻璃体漂浮物对患者的心理状态有负面影响，通过增强的抑郁和焦虑水平。据我们所知,我们的研究是文献中第一个阐述上述关联的研究，通过同时评估三个不同的问卷。
