PDF(Pubmed)
Abstract：
OBJECTIVE: Many pieces of literature have reported that inherited and acquired thrombophilia might be a risk factor for recurrent implantation failure (RIF), however, most studies have only focused on RIF patients and not their male partners. We studied the possible association of paternal thrombophilia with RIF risk.
METHODS: Forty-two male partners aged 20-45 suffered from RIF compared with 42 males from couples with at least one successful pregnancy. All participants were investigated for thrombophilia markers.
RESULTS: The prevalence of coagulation Factor V activity was significantly higher in the case group (42.9%) than in the control group (16.7%) (p=0.008) (OR=3.75; 95% CI, 1.38, 10.12). The prevalence of protein C and protein S deficiencies in RIF patients were 4.8% and 2.4%, respectively, and 0% in the controls. The prevalence of antithrombin III (ATIII) deficiency was significantly higher in the case group (19%) than in the control group (2.4%) (p=0.01). None of MTHFR C677T and MTHFR A1298C were statistically significant between the two groups. Combined thrombophilia was 45.2% in the men of the RIF group when compared with the control, 14.2% (p=0.001) (OR = 4.95; 95% CI, 1.75-13.86).
CONCLUSIONS: Paternal thrombophilia may be related to recurrent implantation failure, so evaluation of this factor in RIF patients could be used to identify relevant risk groups and may help in the proper management of these cases to enhance the chance of implantation.
METHODS: Forty-two male partners aged 20-45 suffered from RIF compared with 42 males from couples with at least one successful pregnancy. All participants were investigated for thrombophilia markers.
RESULTS: The prevalence of coagulation Factor V activity was significantly higher in the case group (42.9%) than in the control group (16.7%) (p=0.008) (OR=3.75; 95% CI, 1.38, 10.12). The prevalence of protein C and protein S deficiencies in RIF patients were 4.8% and 2.4%, respectively, and 0% in the controls. The prevalence of antithrombin III (ATIII) deficiency was significantly higher in the case group (19%) than in the control group (2.4%) (p=0.01). None of MTHFR C677T and MTHFR A1298C were statistically significant between the two groups. Combined thrombophilia was 45.2% in the men of the RIF group when compared with the control, 14.2% (p=0.001) (OR = 4.95; 95% CI, 1.75-13.86).
CONCLUSIONS: Paternal thrombophilia may be related to recurrent implantation failure, so evaluation of this factor in RIF patients could be used to identify relevant risk groups and may help in the proper management of these cases to enhance the chance of implantation.
摘要：
目的：许多文献报道遗传性和获得性血栓形成倾向可能是反复植入失败（RIF）的危险因素，然而,大多数研究只关注RIF患者,而不关注其男性伴侣.我们研究了父系易栓症与RIF风险的可能关联。
方法：42名20-45岁的男性伴侣患有RIF，而42名男性伴侣至少有一次成功怀孕。所有参与者都接受了血栓形成倾向标志物的调查。
结果：病例组凝血因子V活性的患病率（42.9%）明显高于对照组（16.7%）（p=0.008）（OR=3.75；95%CI，1.38，10.12）。RIF患者蛋白C和蛋白S缺乏的患病率分别为4.8%和2.4%,分别,和0％的控制。抗凝血酶III（ATIII）缺乏的患病率在病例组（19％）明显高于对照组（2.4％）（p=0.01）。两组间MTHFRC677T和MTHFRA1298C均无统计学意义。与对照组相比，RIF组男性合并血栓形成率为45.2％，14.2%（p=0.001）（OR=4.95；95%CI，1.75-13.86）。
结论：父系血栓形成倾向可能与反复植入失败有关，因此,在RIF患者中对该因素进行评估可用于确定相关风险组,并可能有助于对这些病例进行适当管理,以提高植入的机会.
方法：42名20-45岁的男性伴侣患有RIF，而42名男性伴侣至少有一次成功怀孕。所有参与者都接受了血栓形成倾向标志物的调查。
结果：病例组凝血因子V活性的患病率（42.9%）明显高于对照组（16.7%）（p=0.008）（OR=3.75；95%CI，1.38，10.12）。RIF患者蛋白C和蛋白S缺乏的患病率分别为4.8%和2.4%,分别,和0％的控制。抗凝血酶III（ATIII）缺乏的患病率在病例组（19％）明显高于对照组（2.4％）（p=0.01）。两组间MTHFRC677T和MTHFRA1298C均无统计学意义。与对照组相比，RIF组男性合并血栓形成率为45.2％，14.2%（p=0.001）（OR=4.95；95%CI，1.75-13.86）。
结论：父系血栓形成倾向可能与反复植入失败有关，因此,在RIF患者中对该因素进行评估可用于确定相关风险组,并可能有助于对这些病例进行适当管理,以提高植入的机会.
