PDF(Pubmed)
Abstract：
UNASSIGNED: To perform a dosimetric comparison between intensity modulated radiotherapy (IMRT) and 3D conformal radiotherapy in patients with locally advanced (stage III and IV) tumours of the supraglottic region treated with conservative surgery and post-operative radiotherapy.
UNASSIGNED: An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered.
UNASSIGNED: IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05).
UNASSIGNED: IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings.
UNASSIGNED: An in-silico plan using a 3D conformal shrinking field technique was retrospectively produced for 20 patients and compared with actually delivered IMRT plans. Eighteen structures (arytenoids, constrictor muscles, base of tongue, floor of mouth, pharyngeal axis, oral cavity, submandibular glands and muscles of the swallowing functional units [SFU]) were considered.
UNASSIGNED: IMRT allowed a reduction of maximum and mean doses to 9 and 14 structures, respectively (p < .05).
UNASSIGNED: IMRT achieved a reduction of unnecessary dose to the remnant larynx and the majority of surrounding SFUs. Further prospective analyses and correlations with functional clinical outcomes are required to confirm these dosimetric findings.
摘要：
■对接受保守手术和术后放疗的声门上区域局部晚期（III期和IV期）肿瘤患者进行调强放疗（IMRT）和3D适形放疗的剂量学比较。
■回顾性地为20例患者制作了使用3D适形收缩场技术的计算机内计划，并与实际交付的IMRT计划进行了比较。18个结构(类芳烃，收缩肌肉，舌根,嘴巴的地板，咽轴,口腔,考虑了吞咽功能单位[SFU]的颌下腺和肌肉）。
■IMRT允许最大和平均剂量减少到9和14个结构，分别（p<0.05）。
■IMRT减少了对残余喉和周围大部分SFU的不必要剂量。需要进一步的前瞻性分析和与功能性临床结果的相关性来确认这些剂量学发现。
■回顾性地为20例患者制作了使用3D适形收缩场技术的计算机内计划，并与实际交付的IMRT计划进行了比较。18个结构(类芳烃，收缩肌肉，舌根,嘴巴的地板，咽轴,口腔,考虑了吞咽功能单位[SFU]的颌下腺和肌肉）。
■IMRT允许最大和平均剂量减少到9和14个结构，分别（p<0.05）。
■IMRT减少了对残余喉和周围大部分SFU的不必要剂量。需要进一步的前瞻性分析和与功能性临床结果的相关性来确认这些剂量学发现。
