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Abstract：
UNASSIGNED: Coronary artery lesion (CAL) is a common yet serious complication in children with Kawasaki disease. The aim of the present study was to evaluate the influencing factors of CAL in children with Kawasaki disease, to provide reference for the clinical treatment and care of children with Kawasaki disease.
UNASSIGNED: A retrospective cohort study.
UNASSIGNED: Children with Kawasaki disease treated in a tertiary hospital in China between 1 January 2021 and 31 December 2022 were selected. The characteristics and clinical data of children with Kawasaki disease were analyzed. Spearman\'s correlation analysis was conducted to evaluate the relationship between CAL and the characteristics of children with Kawasaki disease. A logistic regression analysis was used to analyze the influencing factors of CAL in children with Kawasaki disease.
UNASSIGNED: In total, 185 children with Kawasaki disease were included; the incidence of CAL in children with Kawasaki disease was 18.38%. Pearson\'s correlation analysis showed that gender (r = 0.504), age (r = 0.611), duration of fever ≥10 days (r = 0.579), hemoglobin (Hb) (r = 0.623), and C-reactive protein (CRP) (r = 0.558) were all correlated with the CAL in children with Kawasaki disease (all p < 0.05). Logistic regression analyses showed that male [odds ratio (OR) = 2.543, 95% confidence interval (CI): 1.801-3.077, p = 0.040], age ≤2 years (OR = 3.002, 95% CI: 2.744-3.641, p = 0.012), duration of fever ≥10 days (OR = 2.089, 95% CI: 1.624-2.515, p = 0.028), Hb ≤105 g/L (OR = 1.914, 95% CI: 1.431-2.406, p = 0.013), and CRP ≥100 mg/L (OR = 2.168, 95% CI: 1.893-2.531, p = 0.035) were the risk factors of CAL in children with Kawasaki disease (all p < 0.05).
UNASSIGNED: The incidence of CAL in children with Kawasaki disease is high and there are many related risk factors. Clinical medical workers should take early warning and carry out interventions and nursing care according to these risk factors to improve the prognosis of children with Kawasaki disease.
UNASSIGNED: A retrospective cohort study.
UNASSIGNED: Children with Kawasaki disease treated in a tertiary hospital in China between 1 January 2021 and 31 December 2022 were selected. The characteristics and clinical data of children with Kawasaki disease were analyzed. Spearman\'s correlation analysis was conducted to evaluate the relationship between CAL and the characteristics of children with Kawasaki disease. A logistic regression analysis was used to analyze the influencing factors of CAL in children with Kawasaki disease.
UNASSIGNED: In total, 185 children with Kawasaki disease were included; the incidence of CAL in children with Kawasaki disease was 18.38%. Pearson\'s correlation analysis showed that gender (r = 0.504), age (r = 0.611), duration of fever ≥10 days (r = 0.579), hemoglobin (Hb) (r = 0.623), and C-reactive protein (CRP) (r = 0.558) were all correlated with the CAL in children with Kawasaki disease (all p < 0.05). Logistic regression analyses showed that male [odds ratio (OR) = 2.543, 95% confidence interval (CI): 1.801-3.077, p = 0.040], age ≤2 years (OR = 3.002, 95% CI: 2.744-3.641, p = 0.012), duration of fever ≥10 days (OR = 2.089, 95% CI: 1.624-2.515, p = 0.028), Hb ≤105 g/L (OR = 1.914, 95% CI: 1.431-2.406, p = 0.013), and CRP ≥100 mg/L (OR = 2.168, 95% CI: 1.893-2.531, p = 0.035) were the risk factors of CAL in children with Kawasaki disease (all p < 0.05).
UNASSIGNED: The incidence of CAL in children with Kawasaki disease is high and there are many related risk factors. Clinical medical workers should take early warning and carry out interventions and nursing care according to these risk factors to improve the prognosis of children with Kawasaki disease.
摘要：
■冠状动脉病变（CAL）是川崎病患儿常见但严重的并发症。本研究的目的是评估川崎病患儿CAL的影响因素。为川崎病患儿的临床治疗和护理提供参考。
■一项回顾性队列研究。
■选择2021年1月1日至2022年12月31日在中国三级医院治疗的川崎病儿童。分析川崎病患儿的特点及临床资料。采用Spearman相关分析评价CAL与川崎病患儿特点的关系。采用logistic回归分析川崎病患儿CAL的影响因素。
■总共，纳入185例川崎病患儿；CAL在川崎病患儿中的发病率为18.38%。Pearson相关分析显示，性别(r=0.504)，年龄（r=0.611），发烧持续时间≥10天（r=0.579），血红蛋白（Hb）（r=0.623），C反应蛋白(CRP)(r=0.558)均与川崎病患儿CAL相关(均p<0.05)。Logistic回归分析显示,男性[比值比(OR)=2.543,95%置信区间(CI):1.801-3.077,p=0.040],年龄≤2岁(OR=3.002，95%CI：2.744-3.641，p=0.012)，发烧持续时间≥10天（OR=2.089，95％CI：1.624-2.515，p=0.028），Hb≤105g/L（OR=1.914，95%CI：1.431-2.406，p=0.013），CRP≥100mg/L（OR=2.168，95％CI：1.893-2.531，p=0.035）是川崎病患儿CAL的危险因素（均p<0.05）。
■川崎病患儿CAL的发病率较高，并且有许多相关的危险因素。临床医务工作者应根据这些危险因素进行早期预警和干预护理,以改善川崎病患儿的预后。
■一项回顾性队列研究。
■选择2021年1月1日至2022年12月31日在中国三级医院治疗的川崎病儿童。分析川崎病患儿的特点及临床资料。采用Spearman相关分析评价CAL与川崎病患儿特点的关系。采用logistic回归分析川崎病患儿CAL的影响因素。
■总共，纳入185例川崎病患儿；CAL在川崎病患儿中的发病率为18.38%。Pearson相关分析显示，性别(r=0.504)，年龄（r=0.611），发烧持续时间≥10天（r=0.579），血红蛋白（Hb）（r=0.623），C反应蛋白(CRP)(r=0.558)均与川崎病患儿CAL相关(均p<0.05)。Logistic回归分析显示,男性[比值比(OR)=2.543,95%置信区间(CI):1.801-3.077,p=0.040],年龄≤2岁(OR=3.002，95%CI：2.744-3.641，p=0.012)，发烧持续时间≥10天（OR=2.089，95％CI：1.624-2.515，p=0.028），Hb≤105g/L（OR=1.914，95%CI：1.431-2.406，p=0.013），CRP≥100mg/L（OR=2.168，95％CI：1.893-2.531，p=0.035）是川崎病患儿CAL的危险因素（均p<0.05）。
■川崎病患儿CAL的发病率较高，并且有许多相关的危险因素。临床医务工作者应根据这些危险因素进行早期预警和干预护理,以改善川崎病患儿的预后。
