Abstract：
UNASSIGNED: Remimazolam is an ultrashort-acting benzodiazepine. Few studies have evaluated the effects of remimazolam-based total intravenous anesthesia (TIVA) on emergence agitation (EA). This study aimed to compare the incidence and severity of EA between TIVA using remimazolam and desflurane.
UNASSIGNED: This prospective randomized controlled study enrolled 76 patients who underwent nasal surgery under general anesthesia. Patients were randomized into two groups of 38 each: desflurane-nitrous oxide (N2O) (DN) and remimazolam-remifentanil (RR) groups. The same protocol was used for each group from induction to emergence, except for the use of different anesthetics during maintenance of anesthesia according to the assigned group: desflurane and nitrous oxide for the DN group and remimazolam and remifentanil for the RR group. The incidence of EA as the primary outcome was evaluated using three scales: Ricker Sedation-Agitation Scale, Richmond Agitation-Sedation Scale, and Aono\'s four-point agitation scale. Additionally, hemodynamic changes during emergence and postoperative sense of suffocation were compared.
UNASSIGNED: The incidence of EA was significantly lower in the RR group than in the DN group in all three types of EA assessment scales (all P < 0.001). During emergence, the change in heart rate differed between the two groups (P = 0.002). The sense of suffocation was lower in the RR group than in the DN group (P = 0.027).
UNASSIGNED: RR reduced the incidence and severity of EA in patients undergoing nasal surgery under general anesthesia. In addition, RR was favorable for managing hemodynamics and postoperative sense of suffocation.
UNASSIGNED: This prospective randomized controlled study enrolled 76 patients who underwent nasal surgery under general anesthesia. Patients were randomized into two groups of 38 each: desflurane-nitrous oxide (N2O) (DN) and remimazolam-remifentanil (RR) groups. The same protocol was used for each group from induction to emergence, except for the use of different anesthetics during maintenance of anesthesia according to the assigned group: desflurane and nitrous oxide for the DN group and remimazolam and remifentanil for the RR group. The incidence of EA as the primary outcome was evaluated using three scales: Ricker Sedation-Agitation Scale, Richmond Agitation-Sedation Scale, and Aono\'s four-point agitation scale. Additionally, hemodynamic changes during emergence and postoperative sense of suffocation were compared.
UNASSIGNED: The incidence of EA was significantly lower in the RR group than in the DN group in all three types of EA assessment scales (all P < 0.001). During emergence, the change in heart rate differed between the two groups (P = 0.002). The sense of suffocation was lower in the RR group than in the DN group (P = 0.027).
UNASSIGNED: RR reduced the incidence and severity of EA in patients undergoing nasal surgery under general anesthesia. In addition, RR was favorable for managing hemodynamics and postoperative sense of suffocation.
摘要：
■雷马唑仑是一种超短作用的苯并二氮卓类药物。很少有研究评估以瑞咪唑安定为基础的全静脉麻醉（TIVA）对苏醒期躁动（EA）的影响。本研究旨在比较使用雷米马唑仑和地氟烷的TIVA之间EA的发生率和严重程度。
■这项前瞻性随机对照研究纳入了76名在全身麻醉下接受鼻部手术的患者。患者被随机分为两组，每组38例：地氟醚-一氧化二氮（N2O）（DN）组和瑞马唑仑-瑞芬太尼（RR）组。从诱导到出现，每组使用相同的方案，除了根据分配的组在麻醉维持期间使用不同的麻醉药外:DN组使用地氟醚和一氧化二氮,RR组使用雷米唑仑和瑞芬太尼.EA的发生率作为主要结果使用三个量表进行评估：Ricker镇静-激动量表，里士满激动镇静量表，和Aono的四点激动量表。此外,比较出现时的血流动力学变化和术后窒息感。
■在所有三种类型的EA评估量表中，RR组的EA发生率均显着低于DN组（均P<0.001）。在出现期间,两组患者的心率变化存在差异(P=0.002)。RR组的窒息感低于DN组（P=0.027）。
■RR降低了在全身麻醉下接受鼻腔手术的患者中EA的发生率和严重程度。此外,RR有利于控制血流动力学和术后窒息感。
■这项前瞻性随机对照研究纳入了76名在全身麻醉下接受鼻部手术的患者。患者被随机分为两组，每组38例：地氟醚-一氧化二氮（N2O）（DN）组和瑞马唑仑-瑞芬太尼（RR）组。从诱导到出现，每组使用相同的方案，除了根据分配的组在麻醉维持期间使用不同的麻醉药外:DN组使用地氟醚和一氧化二氮,RR组使用雷米唑仑和瑞芬太尼.EA的发生率作为主要结果使用三个量表进行评估：Ricker镇静-激动量表，里士满激动镇静量表，和Aono的四点激动量表。此外,比较出现时的血流动力学变化和术后窒息感。
■在所有三种类型的EA评估量表中，RR组的EA发生率均显着低于DN组（均P<0.001）。在出现期间,两组患者的心率变化存在差异(P=0.002)。RR组的窒息感低于DN组（P=0.027）。
■RR降低了在全身麻醉下接受鼻腔手术的患者中EA的发生率和严重程度。此外,RR有利于控制血流动力学和术后窒息感。
