Abstract：
Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response. Lysosomal dysfunction is also found to be associated with aging and several diseases. Therefore, function of macroautophagy, a lysosome-dependent intracellular degradation system, has been identified as one of the updated twelve hallmarks of aging. In this review, we begin by introducing the concept of lysosomal quality control (LQC), which is a cellular machinery that maintains the number, morphology, and function of lysosomes through different processes such as lysosomal biogenesis, reformation, fission, fusion, turnover, lysophagy, exocytosis, and membrane permeabilization and repair. Next, we summarize the results from studies reporting the association between LQC dysregulation and aging/various disorders. Subsequently, we explore the emerging therapeutic strategies that target distinct aspects of LQC for treating diseases and combatting aging. Lastly, we underscore the existing knowledge gap and propose potential avenues for future research.
摘要：
以前,溶酶体主要被称为消化细胞器和细胞内的回收中心。最近的发现扩大了溶酶体功能范围，并揭示了它们在营养传感中的关键作用。表观遗传调控，质膜修复,脂质运输，离子稳态，和细胞应激反应。还发现溶酶体功能障碍与衰老和几种疾病有关。因此,巨自噬的功能，依赖溶酶体的细胞内降解系统，已被确定为更新的十二个衰老标志之一。在这次审查中,我们首先介绍溶酶体质量控制（LQC）的概念，这是一个维持数字的蜂窝机器，形态学,和功能的溶酶体通过不同的过程，如溶酶体生物发生，改革,裂变,聚变,营业额，自噬，胞吐作用,和膜透化和修复。接下来,我们总结了LQC失调与衰老/各种疾病之间关联的研究结果.随后，我们探索了针对LQC不同方面的新兴治疗策略，以治疗疾病和对抗衰老。最后,我们强调了现有的知识差距，并提出了未来研究的潜在途径。
