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Abstract：
BACKGROUND: Sepsis is a common syndrome of multiorgan system dysfunction secondary to the dysregulated inflammatory response to infection. The role of pancreatic stone protein (PSP) in diagnosing sepsis has been investigated in previous studies. The meta-analysis aimed to comprehensively investigate the diagnostic value of PSP in identifying sepsis.
METHODS: PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI), were systematically searched. Studies investigating the diagnostic performance of PSP were included. Pooled sensitivity, specificity, positive Likelihood Ratio (+ LR) and negative Likelihood Ratio (-LR), diagnostic odds ratio (DOR), and area under the curve (AUC) of summary receiver operating characteristic (SROC) were calculated.
RESULTS: The sensitivity of PSP was 0.88 (95% CI: 0.77-0.94), and the pooled specificity was 0.78 (95% CI: 0.65-0.87). Pooled + LR, -LR, and DOR were 4.1 (2.3, 7.3), 0.16 (0.07, 0.34), and 26 (7, 98). The AUC value for the SROC of PSP was 0.90 (0.87, 0.92). The pooled sensitivity, specificity, + LR and - LR, and DOR for PSP among neonates were 0.91 (95% CI: 0.84, 0.96), 0.66 (95% CI: 0.58, 0.74), 3.97 (95% CI: 0.53, 29.58), 0.13 (95% CI: 0.02, 1.00), and 31.27 (95% CI: 0.97, 1004.60).
CONCLUSIONS: This study indicates that PSP demonstrated favorable diagnostic accuracy in detecting sepsis. Well-designed studies are warranted to ascertain the value of PSP measurement to guide early empirical antibiotic treatment, particularly in neonates.
METHODS: PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI), were systematically searched. Studies investigating the diagnostic performance of PSP were included. Pooled sensitivity, specificity, positive Likelihood Ratio (+ LR) and negative Likelihood Ratio (-LR), diagnostic odds ratio (DOR), and area under the curve (AUC) of summary receiver operating characteristic (SROC) were calculated.
RESULTS: The sensitivity of PSP was 0.88 (95% CI: 0.77-0.94), and the pooled specificity was 0.78 (95% CI: 0.65-0.87). Pooled + LR, -LR, and DOR were 4.1 (2.3, 7.3), 0.16 (0.07, 0.34), and 26 (7, 98). The AUC value for the SROC of PSP was 0.90 (0.87, 0.92). The pooled sensitivity, specificity, + LR and - LR, and DOR for PSP among neonates were 0.91 (95% CI: 0.84, 0.96), 0.66 (95% CI: 0.58, 0.74), 3.97 (95% CI: 0.53, 29.58), 0.13 (95% CI: 0.02, 1.00), and 31.27 (95% CI: 0.97, 1004.60).
CONCLUSIONS: This study indicates that PSP demonstrated favorable diagnostic accuracy in detecting sepsis. Well-designed studies are warranted to ascertain the value of PSP measurement to guide early empirical antibiotic treatment, particularly in neonates.
摘要：
背景：脓毒症是一种常见的多器官系统功能障碍综合征，继发于对感染的炎症反应失调。先前的研究已经研究了胰石蛋白（PSP）在诊断败血症中的作用。本Meta分析旨在综合探讨PSP对脓毒症的诊断价值。
方法：PubMed，WebofScience,Embase,科克伦图书馆,和中国国家知识基础设施(CNKI)，有系统地搜索。包括调查PSP的诊断性能的研究。汇集灵敏度,特异性，正似然比(+LR)和负似然比(-LR)，诊断优势比(DOR)，计算总受试者工作特征(SROC)的曲线下面积(AUC)。
结果：PSP的敏感性为0.88（95％CI：0.77-0.94），合并特异性为0.78(95%CI:0.65-0.87)。池化+LR,-LR,DOR为4.1（2.3，7.3），0.16(0.07,0.34),和26（7，98）。PSP的SROC的AUC值为0.90(0.87,0.92)。汇集的敏感性，特异性，+LR和-LR，新生儿PSP的DOR为0.91（95％CI：0.84，0.96），0.66（95%CI：0.58，0.74），3.97（95%CI：0.53，29.58），0.13（95%CI：0.02，1.00），和31.27（95%CI：0.97，1004.60）。
结论：本研究表明，PSP在检测脓毒症方面表现出良好的诊断准确性。精心设计的研究有必要确定PSP测量的价值，以指导早期经验性抗生素治疗，尤其是新生儿。
方法：PubMed，WebofScience,Embase,科克伦图书馆,和中国国家知识基础设施(CNKI)，有系统地搜索。包括调查PSP的诊断性能的研究。汇集灵敏度,特异性，正似然比(+LR)和负似然比(-LR)，诊断优势比(DOR)，计算总受试者工作特征(SROC)的曲线下面积(AUC)。
结果：PSP的敏感性为0.88（95％CI：0.77-0.94），合并特异性为0.78(95%CI:0.65-0.87)。池化+LR,-LR,DOR为4.1（2.3，7.3），0.16(0.07,0.34),和26（7，98）。PSP的SROC的AUC值为0.90(0.87,0.92)。汇集的敏感性，特异性，+LR和-LR，新生儿PSP的DOR为0.91（95％CI：0.84，0.96），0.66（95%CI：0.58，0.74），3.97（95%CI：0.53，29.58），0.13（95%CI：0.02，1.00），和31.27（95%CI：0.97，1004.60）。
结论：本研究表明，PSP在检测脓毒症方面表现出良好的诊断准确性。精心设计的研究有必要确定PSP测量的价值，以指导早期经验性抗生素治疗，尤其是新生儿。
