METHODS: PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI), were systematically searched. Studies investigating the diagnostic performance of PSP were included. Pooled sensitivity, specificity, positive Likelihood Ratio (+ LR) and negative Likelihood Ratio (-LR), diagnostic odds ratio (DOR), and area under the curve (AUC) of summary receiver operating characteristic (SROC) were calculated.
RESULTS: The sensitivity of PSP was 0.88 (95% CI: 0.77-0.94), and the pooled specificity was 0.78 (95% CI: 0.65-0.87). Pooled + LR, -LR, and DOR were 4.1 (2.3, 7.3), 0.16 (0.07, 0.34), and 26 (7, 98). The AUC value for the SROC of PSP was 0.90 (0.87, 0.92). The pooled sensitivity, specificity, + LR and - LR, and DOR for PSP among neonates were 0.91 (95% CI: 0.84, 0.96), 0.66 (95% CI: 0.58, 0.74), 3.97 (95% CI: 0.53, 29.58), 0.13 (95% CI: 0.02, 1.00), and 31.27 (95% CI: 0.97, 1004.60).
CONCLUSIONS: This study indicates that PSP demonstrated favorable diagnostic accuracy in detecting sepsis. Well-designed studies are warranted to ascertain the value of PSP measurement to guide early empirical antibiotic treatment, particularly in neonates.
方法:PubMed,WebofScience,Embase,科克伦图书馆,和中国国家知识基础设施(CNKI),有系统地搜索。包括调查PSP的诊断性能的研究。汇集灵敏度,特异性,正似然比(+LR)和负似然比(-LR),诊断优势比(DOR),计算总受试者工作特征(SROC)的曲线下面积(AUC)。
结果:PSP的敏感性为0.88(95%CI:0.77-0.94),合并特异性为0.78(95%CI:0.65-0.87)。池化+LR,-LR,DOR为4.1(2.3,7.3),0.16(0.07,0.34),和26(7,98)。PSP的SROC的AUC值为0.90(0.87,0.92)。汇集的敏感性,特异性,+LR和-LR,新生儿PSP的DOR为0.91(95%CI:0.84,0.96),0.66(95%CI:0.58,0.74),3.97(95%CI:0.53,29.58),0.13(95%CI:0.02,1.00),和31.27(95%CI:0.97,1004.60)。
结论:本研究表明,PSP在检测脓毒症方面表现出良好的诊断准确性。精心设计的研究有必要确定PSP测量的价值,以指导早期经验性抗生素治疗,尤其是新生儿。