Abstract：
OBJECTIVE: Postoperative adhesions can be prevented by the use of bioabsorbable anti-adhesion barriers. Although the occurrence of postoperative bowel obstruction is an important concern for patients, at the time of approval of anti-adhesion barriers, its effectiveness in preventing postoperative bowel obstruction had not been evaluated. We aimed to retrospectively evaluate the incidence of bowel obstruction after colectomy in patients with colon cancer using an insurance claims database.
METHODS: This retrospective cohort study analyzed the data of colon cancer patients (between 2005 and 2017 from a national insurance claims database) who underwent colectomies to compare the proportion of individuals with postoperative bowel obstruction between the barrier and no barrier groups.
RESULTS: Of the 587 patients who met the inclusion criteria, 308 and 279 patients were identified as the barrier and no barrier groups, respectively. The incidence of postoperative bowel obstruction was significantly lower in the barrier group (log-rank test, P = 0.0483). The cumulative incidence of postoperative bowel obstruction 37 months after the initial colectomy was 6.1% and 10.9% in the barrier and no barrier groups, respectively. Moreover, consistent results were obtained in the matched cohort.
CONCLUSIONS: In colectomies for patients with colon cancer, the use of anti-adhesion barriers could significantly reduce the incidence of postoperative bowel obstruction. Evaluations using insurance claims databases could provide important information on outcomes following implementation of medical devices.
METHODS: This retrospective cohort study analyzed the data of colon cancer patients (between 2005 and 2017 from a national insurance claims database) who underwent colectomies to compare the proportion of individuals with postoperative bowel obstruction between the barrier and no barrier groups.
RESULTS: Of the 587 patients who met the inclusion criteria, 308 and 279 patients were identified as the barrier and no barrier groups, respectively. The incidence of postoperative bowel obstruction was significantly lower in the barrier group (log-rank test, P = 0.0483). The cumulative incidence of postoperative bowel obstruction 37 months after the initial colectomy was 6.1% and 10.9% in the barrier and no barrier groups, respectively. Moreover, consistent results were obtained in the matched cohort.
CONCLUSIONS: In colectomies for patients with colon cancer, the use of anti-adhesion barriers could significantly reduce the incidence of postoperative bowel obstruction. Evaluations using insurance claims databases could provide important information on outcomes following implementation of medical devices.
摘要：
目的：可以通过使用生物可吸收的抗粘连屏障来预防术后粘连。尽管术后肠梗阻的发生是患者的重要关注点，在批准抗粘连屏障时，其预防术后肠梗阻的有效性尚未得到评估.我们旨在使用保险索赔数据库回顾性评估结肠癌患者结肠切除术后肠梗阻的发生率。
方法：这项回顾性队列研究分析了接受结肠切除术的结肠癌患者（来自国家保险索赔数据库的2005年至2017年）的数据，以比较屏障组和无屏障组之间术后肠梗阻的个体比例。
结果：在符合纳入标准的587名患者中，308和279名患者被确定为屏障组，无屏障组。分别。术后肠梗阻的发生率在屏障组中显著降低(log-rank检验,P=0.0483)。初次结肠切除术后37个月术后肠梗阻的累积发生率在屏障组和无屏障组分别为6.1%和10.9%,分别。此外，在匹配的队列中获得了一致的结果.
结论：在结肠癌患者的结肠切除术中，使用防粘连屏障可以显著降低术后肠梗阻的发生率.使用保险索赔数据库进行的评估可以提供有关医疗设备实施后结果的重要信息。
方法：这项回顾性队列研究分析了接受结肠切除术的结肠癌患者（来自国家保险索赔数据库的2005年至2017年）的数据，以比较屏障组和无屏障组之间术后肠梗阻的个体比例。
结果：在符合纳入标准的587名患者中，308和279名患者被确定为屏障组，无屏障组。分别。术后肠梗阻的发生率在屏障组中显著降低(log-rank检验,P=0.0483)。初次结肠切除术后37个月术后肠梗阻的累积发生率在屏障组和无屏障组分别为6.1%和10.9%,分别。此外，在匹配的队列中获得了一致的结果.
结论：在结肠癌患者的结肠切除术中，使用防粘连屏障可以显著降低术后肠梗阻的发生率.使用保险索赔数据库进行的评估可以提供有关医疗设备实施后结果的重要信息。
