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Abstract：
To compare the demographic, clinical, and laboratory characteristics, disease onset, and clinical features of radiographic axial Spondyloarthritis (r-axSpA) and non-radiographic axial Spondyloarthritis (nr-axSpA) patients. All patients who attended outpatient spondylarthritis (SpA) clinics at Hospital General de Mexico and the Instituto Nacional de la Nutrición from 1998 to 2005 and met the rheumatologist diagnostic criteria for SpA were selected. Then the SpA patients were classified by European Spondyloarthropathy Study Group criteria (ESSG). We selected SpA patients with axial presentation as axial SpA (axSpA), and they were classified as r-axSpA if they met modified New York (mNY) criteria for sacroiliitis and as nr-axSpA if they did not meet mNY criteria; to compared clinical, demographic, and laboratory test between the subgroups. It included 148 SpA patients; 55 (37.2%) patients had r-axSpA, and 70 (47.3%) had nr-axSpA. The nr-axSpA patients had a lower proportion of males (58.6% vs 78.2%, P < 0.05), lower HLA-B27 frequency (54.3%. vs. 92.7%, P < 0.05), were older at disease onset (21 vs 16 years; P < 0.01) and had a higher frequency of infections at disease onset (9.1% vs 32.9, P < 0.05) than r-axSpA. BASFI (2.9 vs 4.8; P < 0.0001), Dougados functional index (7 vs. 14; P < 0.05), and BASDAI (4.1 vs. 5.2; P < 0.001) were lower in patients with nr-axSpA than r-axSpA, respectively. The factors that most influenced the presentation of r-axSpA were history of uveitis (OR 14, 95% CI 2.3-85), HLA-B27 (OR 7.97, 95% CI, 2.96-122), male sex (OR 6.16, 95% CI, 1.47-25.7), axial enthesopathy count (OR 1.17 95% CI, 1.03-1.33). This study provides insight into the differences between nr-axSpA and r-axSpA in Mexico. Patients with r-axSpA were mainly male, with a younger presentation age, a higher prevalence of HLA-B27, more history of uveitis, fewer episodes of dactylitis, more axial enthesopathy, and higher disease activity than nr-axSpA.
摘要：
为了比较人口统计，临床,和实验室特点，疾病发作,和影像学轴向脊柱关节炎（r-axSpA）和非影像学轴向脊柱关节炎（nr-axSpA）患者的临床特征。选择了1998年至2005年在墨西哥总医院和国家营养研究所的门诊脊椎关节炎（SpA）诊所就诊并符合风湿病学家对SpA的诊断标准的所有患者。然后根据欧洲脊柱关节病研究组标准（ESSG）对SpA患者进行分类。我们选择SpA患者的轴向表现为轴向SpA（axSpA），如果他们符合改良的纽约（mNY）骶髂关节炎标准，他们被归类为r-axSpA；如果他们不符合mNY标准，他们被归类为nr-axSpA；人口统计学,和亚组之间的实验室测试。包括148例SpA患者；55例（37.2％）患者患有r-axSpA，70人(47.3%)患有nr-axSpA。nr-axSpA患者的男性比例较低(58.6%vs78.2%,P<0.05),较低的HLA-B27频率（54.3%。vs.92.7%,P<0.05),发病时年龄较大（21岁vs16岁；P<0.01），发病时感染频率高于r-axSpA（9.1％vs32.9，P<0.05）。BASFI（2.9vs4.8；P<0.0001），Dougados功能指数（7与14；P<0.05），和BASDAI（4.1vs.5.2；P<0.001）在nr-axSpA患者中低于r-axSpA，分别。对r-axSpA表现影响最大的因素是葡萄膜炎病史（OR14，95％CI2.3-85），HLA-B27（OR7.97，95%CI，2.96-122），男性（OR6.16，95%CI，1.47-25.7），眼轴病变计数(OR1.1795%CI,1.03-1.33)。这项研究深入了解了墨西哥nr-axSpA和r-axSpA之间的差异。r-axSpA患者主要为男性,具有较年轻的演讲年龄，HLA-B27患病率较高，葡萄膜炎病史较多，较少发作的指炎,更多的轴向病，和比nr-axSpA更高的疾病活动。
