Abstract：
BACKGROUND: Sexually transmitted infections (STIs) are a major public health concern worldwide. Untreated STIs may have serious sequelae, particularly in pregnant women. The objective of this study was to assess the feasibility and acceptability of screening and treating common STIs in women during pregnancy in Bangladesh.
METHODS: Women were enrolled from four maternity clinics/hospitals serving the lower-middle class population in Dhaka, Bangladesh. The participants were interviewed, and vaginal swab samples were collected by clinical staff. Specimens were tested for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and high-risk Human Papilloma Viruses (HPVs) using GeneXpert (Cepheid, Sunnyvale, California). Women were informed of their test results and were provided treatment for curable infections. A test of cure was performed.
RESULTS: Out of 1157 pregnant women approached, 1000 (86.4%) participated. Ninety-one percent women learned of their test results on the same day of testing. Out of the 996 valid results, 7 (0.7%) tested positive for Chlamydia trachomatis and 1 (0.1%) for Trichomonas vaginalis. There were no gonorrhoea cases. Out of the 971 women with valid results for high-risk HPVs, 46 (4.7%) tested positive.
CONCLUSIONS: Screening women for STIs during antenatal care was highly feasible and well-accepted in Bangladesh. While the prevalence of common curable STIs was very low, hrHPV infection prevalence was moderately high. Our findings support period monitoring of STIs and continued prevention efforts for cervical cancer in Bangladesh.
METHODS: Women were enrolled from four maternity clinics/hospitals serving the lower-middle class population in Dhaka, Bangladesh. The participants were interviewed, and vaginal swab samples were collected by clinical staff. Specimens were tested for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis and high-risk Human Papilloma Viruses (HPVs) using GeneXpert (Cepheid, Sunnyvale, California). Women were informed of their test results and were provided treatment for curable infections. A test of cure was performed.
RESULTS: Out of 1157 pregnant women approached, 1000 (86.4%) participated. Ninety-one percent women learned of their test results on the same day of testing. Out of the 996 valid results, 7 (0.7%) tested positive for Chlamydia trachomatis and 1 (0.1%) for Trichomonas vaginalis. There were no gonorrhoea cases. Out of the 971 women with valid results for high-risk HPVs, 46 (4.7%) tested positive.
CONCLUSIONS: Screening women for STIs during antenatal care was highly feasible and well-accepted in Bangladesh. While the prevalence of common curable STIs was very low, hrHPV infection prevalence was moderately high. Our findings support period monitoring of STIs and continued prevention efforts for cervical cancer in Bangladesh.
摘要：
背景：性传播感染（STIs）是全球主要的公共卫生问题。未经治疗的性传播感染可能会有严重的后遗症，尤其是孕妇。这项研究的目的是评估孟加拉国妊娠期妇女筛查和治疗常见性传播感染的可行性和可接受性。
方法：在达卡为中下阶层人口服务的四家妇产科诊所/医院招募妇女，孟加拉国。参与者接受了采访，和阴道拭子样本由临床工作人员收集。对标本进行了淋病奈瑟菌检测,沙眼衣原体,使用GeneXpert（造父变星，桑尼维尔,California).妇女被告知她们的测试结果，并接受可治愈感染的治疗。进行固化测试。
结果：在1157名孕妇中，1000人（86.4%）参加。百分之九十一的女性在测试的同一天得知了自己的测试结果。在996个有效结果中，沙眼衣原体检测呈阳性的有7例（0.7％），阴道毛滴虫检测呈阳性的有1例（0.1％）。没有淋病病例。在971名获得高风险HPV有效结果的女性中，46（4.7%）检测呈阳性。
结论：在孟加拉国，在产前护理期间对女性进行性传播感染筛查是非常可行和广泛接受的。虽然常见的可治愈性传播感染的患病率很低，hrHPV感染率中等偏高。我们的发现支持孟加拉国性传播感染的定期监测和持续的宫颈癌预防工作。
方法：在达卡为中下阶层人口服务的四家妇产科诊所/医院招募妇女，孟加拉国。参与者接受了采访，和阴道拭子样本由临床工作人员收集。对标本进行了淋病奈瑟菌检测,沙眼衣原体,使用GeneXpert（造父变星，桑尼维尔,California).妇女被告知她们的测试结果，并接受可治愈感染的治疗。进行固化测试。
结果：在1157名孕妇中，1000人（86.4%）参加。百分之九十一的女性在测试的同一天得知了自己的测试结果。在996个有效结果中，沙眼衣原体检测呈阳性的有7例（0.7％），阴道毛滴虫检测呈阳性的有1例（0.1％）。没有淋病病例。在971名获得高风险HPV有效结果的女性中，46（4.7%）检测呈阳性。
结论：在孟加拉国，在产前护理期间对女性进行性传播感染筛查是非常可行和广泛接受的。虽然常见的可治愈性传播感染的患病率很低，hrHPV感染率中等偏高。我们的发现支持孟加拉国性传播感染的定期监测和持续的宫颈癌预防工作。
