Abstract：
UNASSIGNED: To observe the clinical efficacy of calcipotriol combined with AYJ(An Yi Jia) sodium alginate repair dressing in the treatment of psoriasis vulgaris (PV) and its effect on patients\' neurological function.
UNASSIGNED: A retrospective analysis was conducted on the clinical data of 103 patients with PV admitted to our hospital from January 2022 to January 2024. All patients met the inclusion and exclusion criteria. According to the treatment interventions received by the patients, they were divided into control group (n = 51, receiving calcipotriol monotherapy) and observation group (n = 52, receiving calcipotriol combined with AYJ sodium alginate repair dressing). The clinical treatment effects, severity of the disease (PSSI score), levels of T lymphocyte subsets (CD4+, CD8+), serum nerve growth factor (NGF), inflammatory factors [interferon-gamma (IFN-γ), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α)], and adverse reactions were compared between the two groups.
UNASSIGNED: ① Clinical treatment effects: The total effective rate in the observation group was higher than that in the control group (p < 0.05). ② Severity of the disease: The PASI scores of both groups gradually decreased with prolonged treatment time, and the observation group showed a greater magnitude of change (p < 0.05). ③ T lymphocyte subset cells and serum nerve growth factor: The levels of CD4+ were increased after treatment in both groups, while CD8+ and NGF levels were decreased compared to before treatment, with a greater magnitude of change in the observation group (p < 0.05). ④ Inflammatory factors: The levels of IFN-γ, IL-8, and TNF-α were decreased after treatment in both groups, with a greater magnitude of change in the observation group (p < 0.05). ⑤ Adverse reactions: There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05).
UNASSIGNED: Calcipotriol combined with AYJ sodium alginate repair dressing has ideal therapeutic effects in the treatment of PV. Compared with calcipotriol alone, the combined application of AYJ sodium alginate repair dressing can further improve patient efficacy, improve immune and neurological function, alleviate patient inflammatory responses, and does not increase the risk of adverse reactions in patients.
UNASSIGNED: A retrospective analysis was conducted on the clinical data of 103 patients with PV admitted to our hospital from January 2022 to January 2024. All patients met the inclusion and exclusion criteria. According to the treatment interventions received by the patients, they were divided into control group (n = 51, receiving calcipotriol monotherapy) and observation group (n = 52, receiving calcipotriol combined with AYJ sodium alginate repair dressing). The clinical treatment effects, severity of the disease (PSSI score), levels of T lymphocyte subsets (CD4+, CD8+), serum nerve growth factor (NGF), inflammatory factors [interferon-gamma (IFN-γ), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α)], and adverse reactions were compared between the two groups.
UNASSIGNED: ① Clinical treatment effects: The total effective rate in the observation group was higher than that in the control group (p < 0.05). ② Severity of the disease: The PASI scores of both groups gradually decreased with prolonged treatment time, and the observation group showed a greater magnitude of change (p < 0.05). ③ T lymphocyte subset cells and serum nerve growth factor: The levels of CD4+ were increased after treatment in both groups, while CD8+ and NGF levels were decreased compared to before treatment, with a greater magnitude of change in the observation group (p < 0.05). ④ Inflammatory factors: The levels of IFN-γ, IL-8, and TNF-α were decreased after treatment in both groups, with a greater magnitude of change in the observation group (p < 0.05). ⑤ Adverse reactions: There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05).
UNASSIGNED: Calcipotriol combined with AYJ sodium alginate repair dressing has ideal therapeutic effects in the treatment of PV. Compared with calcipotriol alone, the combined application of AYJ sodium alginate repair dressing can further improve patient efficacy, improve immune and neurological function, alleviate patient inflammatory responses, and does not increase the risk of adverse reactions in patients.
摘要：
目的:观察卡泊三醇联合AYJ海藻酸钠修复敷料治疗寻常型银屑病(PV)的临床疗效及对患者神经功能的影响。方法:回顾性分析我院2022年1月至2024年1月收治的103例PV患者的临床资料。所有患者均符合纳入和排除标准。根据患者接受的治疗干预措施，将其分为对照组（n=51，接受卡泊三醇单药治疗）和观察组（n=52，接受卡泊三醇联合AYJ海藻酸钠修复敷料）。临床治疗效果,疾病的严重程度（PSSI评分），T淋巴细胞亚群水平（CD4+，CD8+)，血清神经生长因子（NGF），炎症因子[干扰素-γ（IFN-γ），白细胞介素-8（IL-8），肿瘤坏死因子-α（TNF-α）]，比较两组患者的不良反应。结果:①临床治疗效果:观察组总有效率高于对照组(P<0.05)。②病情严重程度:随着治疗时间的延长,两组PSSI评分均逐渐降低,观察组变化幅度较大(P<0.05)。③T淋巴细胞亚群和血清神经生长因子：两组治疗后CD4+水平均升高，与治疗前相比，CD8+和NGF水平下降，观察组变化幅度较大(P<0.05)。④炎症因子：IFN-γ水平，两组患者治疗后IL-8、TNF-α水平均下降,观察组变化幅度较大(P<0.05)。⑤不良反应:两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡泊三醇联合AYJ海藻酸钠修复敷料治疗PV效果理想。与单独的卡泊三醇相比，AYJ海藻酸钠修复敷料的联合应用可进一步提高患者疗效,改善免疫和神经功能，缓解患者炎症反应，并且不会增加患者不良反应的风险。
