METHODS: A cross-sectional study was conducted at An-Najah National University Hospital (NNUH) in Palestine. The FIB-4 index was calculated using laboratory data for 128 NAFLD patients who underwent liver biopsies between November 2014 and July 2022. The results of FIB-4 were compared with the Scheuer scoring system of liver biopsies (using F0, F1+F2, F3+F4) to determine the sensitivity and specificity of FIB-4 in detecting and staging liver fibrosis.
RESULTS: Out of 128 patients involved in our study, 49 of them had advanced fibrosis according to liver biopsy (F3+F4), where their FIB-4 indices showed 87% sensitivity at 1.45 cut off point and 87% specificity at 3.25 cut off point.
CONCLUSIONS: The FIB-4 index may be used as a screening tool in the primary care setting. To raise awareness of liver diseases, this non-invasive, inexpensive, simple, and quick marker could identify people in need of further liver fibrosis evaluation and diagnosis.
方法:在巴勒斯坦的An-Najah国立大学医院(NNUH)进行了一项横断面研究。使用2014年11月至2022年7月期间接受肝活检的128名NAFLD患者的实验室数据计算FIB-4指数。将FIB-4的结果与肝活检的Scheuer评分系统(使用F0,F1F2,F3F4)进行比较,以确定FIB-4在检测和分期肝纤维化中的敏感性和特异性。
结果:在参与我们研究的128名患者中,根据肝活检(F3+F4),其中49例具有晚期纤维化,他们的FIB-4指数在1.45切点显示87%的敏感性,在3.25切点显示87%的特异性。
结论:FIB-4指数可用作初级保健环境中的筛查工具。提高对肝脏疾病的认识,这种非侵入性的,便宜,简单,和快速标记物可以识别需要进一步肝纤维化评估和诊断的人。