PDF(Pubmed)
Abstract：
On the 26 th January 2023, a free to attend, \'improving in vivo snake venom research: a community discussion\' meeting was held virtually. This webinar brought together researchers from around the world to discuss current neutralisation of venom lethality mouse assays that are used globally to assess the efficacy of therapies for snakebite envenoming. The assay\'s strengths and weaknesses were highlighted, and we discussed what improvements could be made to refine and reduce animal testing, whilst supporting preclinical antivenom and drug discovery for snakebite envenoming. This report summarises the issues highlighted, the discussions held, with additional commentary on key perspectives provided by the authors.
摘要：
2023年1月26日，免费参加，“改善体内蛇毒研究：社区讨论”会议几乎举行。本次网络研讨会汇集了来自世界各地的研究人员，讨论了当前中和毒液致死性小鼠测定法，这些测定法在全球范围内用于评估蛇咬伤envenoming疗法的疗效。强调了该测定的优点和缺点，我们讨论了可以做出哪些改进来改进和减少动物试验，同时支持临床前抗蛇毒血清和蛇咬伤的药物发现。本报告总结了突出的问题，举行的讨论，并对作者提供的关键观点进行了额外的评论。
