PDF(Pubmed)
Abstract：
UNASSIGNED: Antipsychotic drug treatment is a commonly used therapeutic strategy in the field of psychiatry. Rational and standardized use of antipsychotics is crucial in clinical practice, and excessive use of antipsychotics may lead to severe toxic reactions. Thus, attention should be given to the monitoring of drug concentration and examination of organ function.
UNASSIGNED: Excessive use of antipsychotics can cause a variety of adverse effects, including dysfunction of the liver and other organs. Liver cytochrome P450 (CYP450) enzymes play an important role in the metabolism of antipsychotics, and metabolizer types of CYP450 enzymes may influence the therapeutic effects. In this case report, we introduced a 52-year-old woman with a 23-year history of schizophrenia who took excessive doses of multiple antipsychotics and other herbal preparations for nearly 2 years, with poor response to treatment and minor side reactions to the antipsychotics. Pharmacogenomic examination showed that this patient was a CYP1A2 ultra-rapid metabolizer. The examination and treatment of this patient may provide a reference for the management of similar cases with poor response to an alarming tolerance for antipsychotics.
UNASSIGNED: Excessive use of antipsychotics can cause a variety of adverse effects, including dysfunction of the liver and other organs. Liver cytochrome P450 (CYP450) enzymes play an important role in the metabolism of antipsychotics, and metabolizer types of CYP450 enzymes may influence the therapeutic effects. In this case report, we introduced a 52-year-old woman with a 23-year history of schizophrenia who took excessive doses of multiple antipsychotics and other herbal preparations for nearly 2 years, with poor response to treatment and minor side reactions to the antipsychotics. Pharmacogenomic examination showed that this patient was a CYP1A2 ultra-rapid metabolizer. The examination and treatment of this patient may provide a reference for the management of similar cases with poor response to an alarming tolerance for antipsychotics.
摘要：
■抗精神病药物治疗是精神病学领域常用的治疗策略。合理、规范地使用抗精神病药物在临床实践中至关重要,过度使用抗精神病药物可能导致严重的毒性反应。因此，应注意药物浓度的监测和器官功能的检查。
■过度使用抗精神病药会引起多种不良反应，包括肝脏和其他器官的功能障碍。肝细胞色素P450（CYP450）酶在抗精神病药物的代谢中起重要作用，CYP450酶的代谢类型可能会影响治疗效果。在这个案例报告中,我们介绍了一名52岁的女性，有23年的精神分裂症病史，她服用了过量的多种抗精神病药物和其他草药制剂近2年，对治疗反应差，对抗精神病药物有轻微的副反应。药物基因组学检查显示该患者是CYP1A2超快速代谢者。该患者的检查和治疗可为类似病例的处理提供参考，这些病例对抗精神病药的耐受性令人震惊。
■过度使用抗精神病药会引起多种不良反应，包括肝脏和其他器官的功能障碍。肝细胞色素P450（CYP450）酶在抗精神病药物的代谢中起重要作用，CYP450酶的代谢类型可能会影响治疗效果。在这个案例报告中,我们介绍了一名52岁的女性，有23年的精神分裂症病史，她服用了过量的多种抗精神病药物和其他草药制剂近2年，对治疗反应差，对抗精神病药物有轻微的副反应。药物基因组学检查显示该患者是CYP1A2超快速代谢者。该患者的检查和治疗可为类似病例的处理提供参考，这些病例对抗精神病药的耐受性令人震惊。
