PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic complications post-lung transplant are poorly understood and little is known about how these complications differ between patients with or without cystic fibrosis (pwCF and pwoCF). This study compared post-lung transplant outcomes between pwCF and pwoCF relating to survival and incidence of diabetes, dyslipidaemia, hypertension, and renal impairment.
UNASSIGNED: A retrospective (2004-2017) case-control study involving 90 pwCF and 90 pwoCF (age, sex and year of transplant matched) was conducted. Demographic variables, pre/post-transplant metabolic diseases, blood investigations and medications were extracted. Descriptive statistics were used to describe the cohort. Mann-Whitney U and Chi-squared tests were used to analyse morbidity and mortality data. Regression analyses were used to identity independent variables that impacted clinical outcomes. Kaplan Meier analysis with log-rank testing was used to compare survival.
UNASSIGNED: PwCF were younger, had lower BMIs, and were less likely to have pre-transplant extracorporeal membrane oxygenation (ECMO) use. A total of 37 pwCF and 41 pwoCF died (p = 0.65) during the period of observation with no differences in survival. Adjusting for covariates of age, sex and BMI via multiple logistic regression, CF status was associated with a dramatic increased risk of new-onset diabetes post-transplant (adjusted odds ratio 28.7; 95 % CI, 28.76 to 108.7). No other differences in adjusted risk were found.
UNASSIGNED: As pwCF had a greater adjusted risk of developing new post-transplant diabetes and experienced metabolic complications at similar rates as pwoCF, the findings highlight the need for rigorous monitoring of pwCF for possible metabolic complications post-transplant.
UNASSIGNED: A retrospective (2004-2017) case-control study involving 90 pwCF and 90 pwoCF (age, sex and year of transplant matched) was conducted. Demographic variables, pre/post-transplant metabolic diseases, blood investigations and medications were extracted. Descriptive statistics were used to describe the cohort. Mann-Whitney U and Chi-squared tests were used to analyse morbidity and mortality data. Regression analyses were used to identity independent variables that impacted clinical outcomes. Kaplan Meier analysis with log-rank testing was used to compare survival.
UNASSIGNED: PwCF were younger, had lower BMIs, and were less likely to have pre-transplant extracorporeal membrane oxygenation (ECMO) use. A total of 37 pwCF and 41 pwoCF died (p = 0.65) during the period of observation with no differences in survival. Adjusting for covariates of age, sex and BMI via multiple logistic regression, CF status was associated with a dramatic increased risk of new-onset diabetes post-transplant (adjusted odds ratio 28.7; 95 % CI, 28.76 to 108.7). No other differences in adjusted risk were found.
UNASSIGNED: As pwCF had a greater adjusted risk of developing new post-transplant diabetes and experienced metabolic complications at similar rates as pwoCF, the findings highlight the need for rigorous monitoring of pwCF for possible metabolic complications post-transplant.
摘要：
■人们对肺移植后的代谢并发症知之甚少，对这些并发症在有或没有囊性纤维化（pwCF和pwoCF）的患者之间的差异知之甚少。这项研究比较了pwCF和pwoCF在肺移植后的结果与生存率和糖尿病发病率有关。血脂异常,高血压,和肾功能损害。
■一项回顾性（2004-2017年）病例对照研究，涉及90pwCF和90pwoCF（年龄，性别和移植年份匹配)进行。人口统计变量，移植前/移植后代谢疾病，血液调查和药物提取。使用描述性统计来描述队列。使用Mann-WhitneyU和卡方检验分析发病率和死亡率数据。回归分析用于确定影响临床结果的独立变量。使用具有对数秩检验的KaplanMeier分析来比较存活率。
■PwCF更年轻，有较低的BMI，并且不太可能使用移植前体外膜氧合（ECMO）。在观察期间，共有37pwCF和41pwoCF死亡（p=0.65），生存率无差异。调整年龄的协变量，性别和BMI通过多元逻辑回归，CF状态与移植后新发糖尿病风险显著增加相关(调整后比值比28.7;95%CI,28.76-108.7)。没有发现调整后风险的其他差异。
■由于pwCF有更大的调整后发生新的移植后糖尿病的风险，并且经历了与pwoCF相似的代谢并发症，研究结果强调,有必要对移植后可能出现的代谢并发症进行pwCF严格监测.
■一项回顾性（2004-2017年）病例对照研究，涉及90pwCF和90pwoCF（年龄，性别和移植年份匹配)进行。人口统计变量，移植前/移植后代谢疾病，血液调查和药物提取。使用描述性统计来描述队列。使用Mann-WhitneyU和卡方检验分析发病率和死亡率数据。回归分析用于确定影响临床结果的独立变量。使用具有对数秩检验的KaplanMeier分析来比较存活率。
■PwCF更年轻，有较低的BMI，并且不太可能使用移植前体外膜氧合（ECMO）。在观察期间，共有37pwCF和41pwoCF死亡（p=0.65），生存率无差异。调整年龄的协变量，性别和BMI通过多元逻辑回归，CF状态与移植后新发糖尿病风险显著增加相关(调整后比值比28.7;95%CI,28.76-108.7)。没有发现调整后风险的其他差异。
■由于pwCF有更大的调整后发生新的移植后糖尿病的风险，并且经历了与pwoCF相似的代谢并发症，研究结果强调,有必要对移植后可能出现的代谢并发症进行pwCF严格监测.
