PDF(Pubmed)
Abstract：
BACKGROUND: Certain studies have indicated a link between obstructive sleep apnea and insulin resistance in specific populations. To gain more clarity, extensive research involving a broad sample of the overall population is essential. The primary objective of this study was to investigate this correlation by utilizing data from the National Health and Nutrition Examination Survey database.
METHODS: The analysis incorporated data from the National Health and Nutrition Examination Survey database spanning the time periods from 2005 to 2008 and from 2015 to 2018, with a focus on American adults aged 18 years and older after applying weight adjustments. Key variables such as obstructive sleep apnea, triglyceride glucose index, and various confounding factors were considered. A generalized linear logistic regression model was used to investigate the association between obstructive sleep apnea and the triglyceride glucose index, with additional exploration of the consistency of the results through hierarchical analysis and other techniques.
RESULTS: The study included participants aged between 18 and 90 years, with an average age of 46.75 years. Among the total sample, 50.76% were male. The triglyceride glucose index demonstrated a diagnostic capability for obstructive sleep apnea, with an AUC of 0.701 (95% CI: 0.6619-0.688). According to the fully adjusted model, individuals in the fourth quartile of the triglyceride glucose index showed an increased likelihood of having obstructive sleep apnea compared to those in the first quartile (OR: 1.45; 95% CI: 1.02-2.06; P < 0.05). Subgroup analysis indicated that male sex (OR: 2.09; 95% CI: 1.76-2.45; P < 0.05), younger age (OR: 2.83; 95% CI: 2.02-3.96; P < 0.05), white ethnicity (OR: 2.29; 95% CI: 1.93-2.73; P < 0.05), and obesity (OR: 1.54; 95% CI: 1.28-1.85; P < 0.05) were correlated with an elevated risk of OSA.
CONCLUSIONS: This study demonstrated a strong association between an elevated TG index and OSA. Additionally, the triglyceride glucose index could serve as an independent predictor of obstructive sleep apnea.
METHODS: The analysis incorporated data from the National Health and Nutrition Examination Survey database spanning the time periods from 2005 to 2008 and from 2015 to 2018, with a focus on American adults aged 18 years and older after applying weight adjustments. Key variables such as obstructive sleep apnea, triglyceride glucose index, and various confounding factors were considered. A generalized linear logistic regression model was used to investigate the association between obstructive sleep apnea and the triglyceride glucose index, with additional exploration of the consistency of the results through hierarchical analysis and other techniques.
RESULTS: The study included participants aged between 18 and 90 years, with an average age of 46.75 years. Among the total sample, 50.76% were male. The triglyceride glucose index demonstrated a diagnostic capability for obstructive sleep apnea, with an AUC of 0.701 (95% CI: 0.6619-0.688). According to the fully adjusted model, individuals in the fourth quartile of the triglyceride glucose index showed an increased likelihood of having obstructive sleep apnea compared to those in the first quartile (OR: 1.45; 95% CI: 1.02-2.06; P < 0.05). Subgroup analysis indicated that male sex (OR: 2.09; 95% CI: 1.76-2.45; P < 0.05), younger age (OR: 2.83; 95% CI: 2.02-3.96; P < 0.05), white ethnicity (OR: 2.29; 95% CI: 1.93-2.73; P < 0.05), and obesity (OR: 1.54; 95% CI: 1.28-1.85; P < 0.05) were correlated with an elevated risk of OSA.
CONCLUSIONS: This study demonstrated a strong association between an elevated TG index and OSA. Additionally, the triglyceride glucose index could serve as an independent predictor of obstructive sleep apnea.
摘要：
背景：某些研究表明，在特定人群中，阻塞性睡眠呼吸暂停与胰岛素抵抗之间存在联系。为了获得更多的清晰度，涉及总体人口的广泛样本的广泛研究是必不可少的。这项研究的主要目的是通过利用国家健康和营养检查调查数据库中的数据来调查这种相关性。
方法：该分析纳入了2005年至2008年和2015年至2018年的国家健康和营养检查数据库中的数据，重点是18岁及以上的美国成年人在应用体重调整后。关键变量，如阻塞性睡眠呼吸暂停，甘油三酯葡萄糖指数，并考虑了各种混杂因素。使用广义线性logistic回归模型来研究阻塞性睡眠呼吸暂停与甘油三酯葡萄糖指数之间的关系。并通过层次分析法和其他技术对结果的一致性进行了额外的探索。
结果：该研究包括年龄在18至90岁之间的参与者，平均年龄为46.75岁。在总样本中，50.76%为男性。甘油三酯葡萄糖指数显示了对阻塞性睡眠呼吸暂停的诊断能力，AUC为0.701（95%CI：0.6619-0.688）。根据完全调整的模型，与第1四分位数的个体相比,第4四分位数的个体患阻塞性睡眠呼吸暂停的可能性增加(OR:1.45;95%CI:1.02~2.06;P<0.05).亚组分析显示男性(OR:2.09;95%CI:1.76~2.45;P<0.05),年龄较小（OR：2.83；95％CI：2.02-3.96；P<0.05），白人种族（OR：2.29；95％CI：1.93-2.73；P<0.05），肥胖(OR:1.54;95%CI:1.28-1.85;P<0.05)与OSA风险升高相关。
结论：本研究表明，TG指数升高与OSA有很强的相关性。此外,甘油三酯葡萄糖指数可作为阻塞性睡眠呼吸暂停的独立预测因子.
方法：该分析纳入了2005年至2008年和2015年至2018年的国家健康和营养检查数据库中的数据，重点是18岁及以上的美国成年人在应用体重调整后。关键变量，如阻塞性睡眠呼吸暂停，甘油三酯葡萄糖指数，并考虑了各种混杂因素。使用广义线性logistic回归模型来研究阻塞性睡眠呼吸暂停与甘油三酯葡萄糖指数之间的关系。并通过层次分析法和其他技术对结果的一致性进行了额外的探索。
结果：该研究包括年龄在18至90岁之间的参与者，平均年龄为46.75岁。在总样本中，50.76%为男性。甘油三酯葡萄糖指数显示了对阻塞性睡眠呼吸暂停的诊断能力，AUC为0.701（95%CI：0.6619-0.688）。根据完全调整的模型，与第1四分位数的个体相比,第4四分位数的个体患阻塞性睡眠呼吸暂停的可能性增加(OR:1.45;95%CI:1.02~2.06;P<0.05).亚组分析显示男性(OR:2.09;95%CI:1.76~2.45;P<0.05),年龄较小（OR：2.83；95％CI：2.02-3.96；P<0.05），白人种族（OR：2.29；95％CI：1.93-2.73；P<0.05），肥胖(OR:1.54;95%CI:1.28-1.85;P<0.05)与OSA风险升高相关。
结论：本研究表明，TG指数升高与OSA有很强的相关性。此外,甘油三酯葡萄糖指数可作为阻塞性睡眠呼吸暂停的独立预测因子.
