Abstract：
UNASSIGNED: It is unclear of the correlation between a mild traumatic brain injury (mTBI) and repeated subconcussive (RSC) impacts with respect to injury biomechanics. Thus, the present study was designed to determine the behavioral and histological differences between a single mTBI impact and RSC impacts with subdivided cumulative kinetic energies of the single mTBI impact.
UNASSIGNED: Adult male Sprague-Dawley rats were randomly assigned to a single mTBI impact, RSC impact, sham, or repeated sham groups.
UNASSIGNED: Following a weight drop injury, anxiety-like behavior and general locomotive activity and were assessed using the open field test, while motor coordination was evaluated using a rotarod unit. Neuronal loss, astrogliosis, and microgliosis were assessed using NeuN, GFAP and Iba-1 immunohistochemistry. All assessments were undertaken at 3- and 7-days post impact.
UNASSIGNED: No behavioral disturbances were observed in injury groups, however, both injury groups did lead to microgliosis following 3-days post-impact.
UNASSIGNED: No pathophysiological differences were observed between a single mTBI impact and RSC impacts of the same energy input. Even though a cumulative injury threshold for RSC impacts was not determined, a threshold still may exist where no pathodynamic shift occurs.
UNASSIGNED: Adult male Sprague-Dawley rats were randomly assigned to a single mTBI impact, RSC impact, sham, or repeated sham groups.
UNASSIGNED: Following a weight drop injury, anxiety-like behavior and general locomotive activity and were assessed using the open field test, while motor coordination was evaluated using a rotarod unit. Neuronal loss, astrogliosis, and microgliosis were assessed using NeuN, GFAP and Iba-1 immunohistochemistry. All assessments were undertaken at 3- and 7-days post impact.
UNASSIGNED: No behavioral disturbances were observed in injury groups, however, both injury groups did lead to microgliosis following 3-days post-impact.
UNASSIGNED: No pathophysiological differences were observed between a single mTBI impact and RSC impacts of the same energy input. Even though a cumulative injury threshold for RSC impacts was not determined, a threshold still may exist where no pathodynamic shift occurs.
摘要：
■尚不清楚轻度创伤性脑损伤（mTBI）与反复的脑震荡（RSC）冲击之间在损伤生物力学方面的相关性。因此，本研究旨在确定单个mTBI冲击和RSC冲击之间的行为和组织学差异，并细分了单个mTBI冲击的累积动能。
■成年雄性Sprague-Dawley大鼠被随机分配到单个mTBI冲击中，RSC影响,sham,或重复的假团体。
■体重下降后受伤，焦虑样行为和一般机车活动，并使用开场测试进行评估，而运动协调是使用旋转杆单元进行评估的。神经元丢失,星形胶质增生,和小胶质细胞增生使用NeuN进行评估，GFAP和Iba-1免疫组织化学。所有评估均在影响后3天和7天进行。
■在损伤组中未观察到行为障碍，然而,两个损伤组均在撞击后3天后导致小胶质细胞增生.
■在相同能量输入的单个mTBI冲击和RSC冲击之间没有观察到病理生理学差异。即使RSC影响的累积损伤阈值尚未确定，阈值仍然可能存在，其中没有发生病理动态偏移。
■成年雄性Sprague-Dawley大鼠被随机分配到单个mTBI冲击中，RSC影响,sham,或重复的假团体。
■体重下降后受伤，焦虑样行为和一般机车活动，并使用开场测试进行评估，而运动协调是使用旋转杆单元进行评估的。神经元丢失,星形胶质增生,和小胶质细胞增生使用NeuN进行评估，GFAP和Iba-1免疫组织化学。所有评估均在影响后3天和7天进行。
■在损伤组中未观察到行为障碍，然而,两个损伤组均在撞击后3天后导致小胶质细胞增生.
■在相同能量输入的单个mTBI冲击和RSC冲击之间没有观察到病理生理学差异。即使RSC影响的累积损伤阈值尚未确定，阈值仍然可能存在，其中没有发生病理动态偏移。
