Abstract：
Clinical therapy for widespread infections caused by Streptococcus pneumoniae (S. pneumoniae), such as community-acquired pneumonia, is highly challenging. As an important bacterial toxin, hydrogen peroxide (H2O2) secreted by S. pneumoniae can suppress the host\'s immune system and cause more severe disease. To address this problem, a hyaluronic acid (HA)-coated inorganic catalase-driven Janus nanomotor was developed, which can cleverly utilize and decompose H2O2 to reduce the burden of bacterial infection, and have excellent drug loading capacity. HA coating prevents rapid leakage of loaded antibiotics and improves the biocompatibility of the nanomaterials. The Janus nanomotor converted H2O2 into oxygen (O2), gave itself the capacity to move actively, and encouraged widespread dispersion in the lesion site. Encouragingly, animal experiments demonstrated that the capability of the nanomotors to degrade H2O2 contributes to diminishing the proliferation of S. pneumoniae and lung tissue damage. This self-propelled drug delivery platform provides a new therapeutic strategy for infections with toxin-secreting bacteria.
摘要：
肺炎链球菌引起的广泛感染的临床治疗（S.肺炎），比如社区获得性肺炎,极具挑战性。作为一种重要的细菌毒素,肺炎链球菌分泌的过氧化氢(H2O2)可抑制宿主的免疫系统,引起更严重的疾病。为了解决这个问题,开发了一种透明质酸（HA）涂层的无机过氧化氢酶驱动的Janus纳米马达，能巧妙地利用和分解H2O2，减轻细菌感染的负担，并具有优异的药物装载能力。HA涂层可防止负载抗生素的快速泄漏，并改善纳米材料的生物相容性。Janus纳米马达将H2O2转化为氧气（O2），给了自己积极行动的能力，并促进病变部位的广泛分散。令人鼓舞的是，动物实验表明，纳米马达降解H2O2的能力有助于减少肺炎链球菌的增殖和肺组织损伤。这种自走式药物递送平台为分泌毒素的细菌感染提供了新的治疗策略。
