Abstract：
OBJECTIVE: Various aspects of the concept of Vyadhikshamatva have been thoroughly explored, highlighting its profound significance in resisting disease manifestation, particularly in the context of Ankylosing spondylitis. Investigated the relationship between HLA-B27 and Ankylosing spondylitis (AS) by examining current knowledge and hypotheses Furthermore, efforts were made to portray the influence of prakruti (constitution) and balam (strength) on disease manifestation and progression.
METHODS: Ayurvedic literature along with contemporary research works was analyzed for correlating various aspects like vyadhikshamatva,oja (The final essence of all body elements), and balam along with their influence on the defensive mechanism of the body. A thorough literature search was conducted to explore the strong association between HLA-B27 and AS by examining various hypotheses like the Arthritogenic peptide hypothesis, the Misfolding hypothesis, the Surface Homodimer hypothesis, and the β2 microglobulin hypothesis that attempts to explain the pathogenic role of HLA-B27 in AS. Alongside classical Ayurvedic texts, databases like PubMed and Scopus were searched using keywords such as Immunity, Ankylosing spondylitis, Vyadhikshamatva, HLA-B27, Balam, and Autoimmune disorder with the help of Boolean operators.
RESULTS: The review highlighted the critical role of Vyadhikshamatva in disease prevention, particularly in influencing the manifestation of conditions like AS despite genetic predisposition (HLA-B27). Further, the understanding of the Ayurvedic concepts can clearly explain the conflict that has arisen in the determination of the positive HLAB27 gene in Ankylosing Spondylitis as a definite diagnosing criteria.
CONCLUSIONS: This comprehensive understanding will uplift the need for personalized medicine in disease management. Further research must be needed to understand the interaction between genetic factors (HLAb27), individual constitution, and their vyadikshamatva.
METHODS: Ayurvedic literature along with contemporary research works was analyzed for correlating various aspects like vyadhikshamatva,oja (The final essence of all body elements), and balam along with their influence on the defensive mechanism of the body. A thorough literature search was conducted to explore the strong association between HLA-B27 and AS by examining various hypotheses like the Arthritogenic peptide hypothesis, the Misfolding hypothesis, the Surface Homodimer hypothesis, and the β2 microglobulin hypothesis that attempts to explain the pathogenic role of HLA-B27 in AS. Alongside classical Ayurvedic texts, databases like PubMed and Scopus were searched using keywords such as Immunity, Ankylosing spondylitis, Vyadhikshamatva, HLA-B27, Balam, and Autoimmune disorder with the help of Boolean operators.
RESULTS: The review highlighted the critical role of Vyadhikshamatva in disease prevention, particularly in influencing the manifestation of conditions like AS despite genetic predisposition (HLA-B27). Further, the understanding of the Ayurvedic concepts can clearly explain the conflict that has arisen in the determination of the positive HLAB27 gene in Ankylosing Spondylitis as a definite diagnosing criteria.
CONCLUSIONS: This comprehensive understanding will uplift the need for personalized medicine in disease management. Further research must be needed to understand the interaction between genetic factors (HLAb27), individual constitution, and their vyadikshamatva.
摘要：
目的：Vyadhikshamatva概念的各个方面已经被彻底探索，突出了它在抵抗疾病表现方面的深远意义，特别是在强直性脊柱炎的背景下。通过检查当前的知识和假设，研究HLA-B27与强直性脊柱炎（AS）之间的关系。努力描绘prakruti（体质）和balam（力量）对疾病表现和进展的影响。
方法：分析了阿育吠陀文献以及当代研究工作，以将vyadhikshamatva等各个方面相关联，Oja（所有身体元素的最终本质），和balam以及它们对身体防御机制的影响。进行了彻底的文献检索，以通过检查各种假设，如Arthrentogenic肽假说，探索HLA-B27和AS之间的强关联。错误折叠的假设，表面同源二聚体假说，和试图解释HLA-B27在AS中的致病作用的β2微球蛋白假说。除了经典的阿育吠陀文本，像PubMed和Scopus这样的数据库使用诸如Immunity之类的关键字进行搜索，强直性脊柱炎,Vyadhikshamatva,HLA-B27巴拉姆,以及在布尔运算符的帮助下的自身免疫性疾病。
结果：评论强调了Vyadhikshamatva在疾病预防中的关键作用，特别是影响AS等疾病的表现，尽管有遗传易感性（HLA-B27）。Further,对阿育吠陀概念的理解可以清楚地解释在确定强直性脊柱炎中HLAB27基因阳性作为明确的诊断标准时出现的冲突。
结论：这种全面的理解将提高对疾病管理中个性化医疗的需求。必须进一步研究以了解遗传因素之间的相互作用（HLAb27），个人宪法,还有他们的vyadikshamatva.
方法：分析了阿育吠陀文献以及当代研究工作，以将vyadhikshamatva等各个方面相关联，Oja（所有身体元素的最终本质），和balam以及它们对身体防御机制的影响。进行了彻底的文献检索，以通过检查各种假设，如Arthrentogenic肽假说，探索HLA-B27和AS之间的强关联。错误折叠的假设，表面同源二聚体假说，和试图解释HLA-B27在AS中的致病作用的β2微球蛋白假说。除了经典的阿育吠陀文本，像PubMed和Scopus这样的数据库使用诸如Immunity之类的关键字进行搜索，强直性脊柱炎,Vyadhikshamatva,HLA-B27巴拉姆,以及在布尔运算符的帮助下的自身免疫性疾病。
结果：评论强调了Vyadhikshamatva在疾病预防中的关键作用，特别是影响AS等疾病的表现，尽管有遗传易感性（HLA-B27）。Further,对阿育吠陀概念的理解可以清楚地解释在确定强直性脊柱炎中HLAB27基因阳性作为明确的诊断标准时出现的冲突。
结论：这种全面的理解将提高对疾病管理中个性化医疗的需求。必须进一步研究以了解遗传因素之间的相互作用（HLAb27），个人宪法,还有他们的vyadikshamatva.
