染色质修饰剂的可变剪接改变了干细胞维持和神经元分化的转录调节程序。
关键词: BAF complex DPF2 PTBP1 alternative splicing chromatin remodeling embryonic stem cell histone modification mammalian SWI/SNF complex neuronal differentiation transcription
Mesh : Alternative Splicing / genetics Polypyrimidine Tract-Binding Protein / metabolism genetics Animals Cell Differentiation / genetics Chromatin / metabolism Mice Neurons / metabolism cytology Transcription Factors / metabolism genetics Heterogeneous-Nuclear Ribonucleoproteins / metabolism genetics DNA-Binding Proteins / metabolism genetics Transcription, Genetic Embryonic Stem Cells / metabolism cytology Exons / genetics Humans Cell Self Renewal / genetics
来 源:
DOI:10.1016/j.stem.2024.04.001
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