Abstract：
Marine natural products play an important role in biopesticides. Seven new secondary metabolites with different structural classes, including two cycloheptapeptides, scortide A (1) and scortide B (2), two 19-nor-diterpenoids, talascortene H (3) and talascortene I (4), two diterpenoid acids, talascortene J (5) and talascortene K (6), and one triterpenoid, talascortene L (7) were isolated and identified from the sea-anemone-derived endozoic fungus Talaromyces scorteus AS-242. Their structures were comprehensively assigned by spectroscopic data analysis, single-crystal X-ray diffraction, tandem mass spectrometry, and electronic circular dichroism (ECD) calculations. The result of the antimicrobial assay demonstrated that compounds 1 - 6 have inhibitory activity against several human, aquatic, and plant pathogens with minimum inhibitory concentration (MIC) values ranging from 1 to 64 μg/mL. Specially, compounds 2 and 4 showed significant activities against the pathogenic fungus Curvularia spicifera with the MIC value of 1 μg/mL, providing an experimental basis of 2 and 4 with the potential as lead compounds to be developed into biopesticides.
摘要：
海洋天然产物在生物农药中发挥着重要作用。七种具有不同结构类型的新次级代谢产物，包括两个环七肽，sortideA（1）和sortideB（2），两种19-nor-二萜，滑石抗坏血酸烯H(3)和滑石抗坏血酸烯I(4)，两种二萜酸，滑石抗坏血酸烯J(5)和滑石抗坏血酸烯K(6)，和一种三萜类化合物，从海葵衍生的内生真菌TalaromycesscorteusAS-242中分离并鉴定了tal抗坏血酸L（7）。通过光谱数据分析对它们的结构进行了全面分配，单晶X射线衍射,串联质谱,和电子圆二色性（ECD）计算。抗菌试验结果表明，化合物1-6对几种人具有抑制活性，水生,和最低抑制浓度（MIC）值在1至64μg/mL范围内的植物病原体。特别是,化合物2和4对致病真菌弯孢菌均有显著的活性,MIC值为1μg/mL,提供2和4的实验基础，有可能作为先导化合物开发为生物农药。
