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Abstract：
BACKGROUND: Compared with traditional root canal therapy (RCT), vital pulp therapy (VPT) is a personalized and minimally invasive method for the treatment of pulpitis caused by dental caries. However, there are still no clear guidelines for VPT because high-quality randomized clinical trials are scarce. This prospective cohort study evaluated the clinical efficacy of VPT with the light-curable calcium silicate-based material TheraCal LC (TH) and bioceramic material iRoot BP Plus (BP) in reversible and irreversible pulpitis permanent teeth with carious exposures.
METHODS: 115 teeth with reversible or irreversible pulpitis caused by deep care were randomly divided into 2 groups. TheraCal LC and iRoot BP Plus were used for the pulp capping. Direct pulp capping (DPC), partial pulpotomy (PP) and full pulpotomy (FP) were performed based on observation of the exposed pulp. Postoperative discomforts were enquired and recorded via follow-up phone calls. Clinical and radiographic evaluations were performed 3, 6, and 12 months postoperatively.
RESULTS: The overall clinical success rate in the first year was 90.4% (47/52) in both groups. The TH group required less operating time, showed lower levels of pain, and had shorter pain duration post-operative (P < .001). According to the binary logistic regression model, preoperative pain duration was significantly correlated with the prognosis of VPT (P = .011).
CONCLUSIONS: VPT with TheraCal LC and iRoot BP Plus in pulpitis permanent carious teeth both achieved good clinical outcomes, and TheraCal LC can be easily operated for clinical use. Preoperative pain duration of the affected tooth might have a significant correlation with the prognosis of VPT.
METHODS: 115 teeth with reversible or irreversible pulpitis caused by deep care were randomly divided into 2 groups. TheraCal LC and iRoot BP Plus were used for the pulp capping. Direct pulp capping (DPC), partial pulpotomy (PP) and full pulpotomy (FP) were performed based on observation of the exposed pulp. Postoperative discomforts were enquired and recorded via follow-up phone calls. Clinical and radiographic evaluations were performed 3, 6, and 12 months postoperatively.
RESULTS: The overall clinical success rate in the first year was 90.4% (47/52) in both groups. The TH group required less operating time, showed lower levels of pain, and had shorter pain duration post-operative (P < .001). According to the binary logistic regression model, preoperative pain duration was significantly correlated with the prognosis of VPT (P = .011).
CONCLUSIONS: VPT with TheraCal LC and iRoot BP Plus in pulpitis permanent carious teeth both achieved good clinical outcomes, and TheraCal LC can be easily operated for clinical use. Preoperative pain duration of the affected tooth might have a significant correlation with the prognosis of VPT.
摘要：
背景：与传统根管治疗（RCT）相比，重要牙髓疗法（VPT）是一种个性化的微创治疗龋齿引起的牙髓炎的方法。然而,由于缺乏高质量的随机临床试验,目前尚没有明确的VPT指南.这项前瞻性队列研究评估了使用光固化硅酸钙基材料TheraCalLC（TH）和生物陶瓷材料iRootBPPlus（BP）在可逆和不可逆牙髓炎恒牙中进行VPT的临床疗效。
方法：115颗因深层护理引起的可逆性或不可逆性牙髓炎的牙齿随机分为2组。TheraCalLC和iRootBPPlus用于纸浆封盖。直接盖浆(DPC),根据对暴露牙髓的观察，进行部分牙髓切除术（PP）和完全牙髓切除术（FP）。通过随访电话询问并记录了术后不适。术后3、6和12个月进行临床和影像学评估。
结果：两组第一年的总体临床成功率均为90.4％（47/52）。TH组需要较少的操作时间，显示较低的疼痛程度，术后疼痛持续时间较短(P<.001)。根据二元逻辑回归模型，术前疼痛持续时间与VPT预后显著相关(P=.011).
结论：VPT联合TheraCalLC和iRootBPPlus在牙髓炎恒牙龋齿中均取得了良好的临床效果，和TheraCalLC可以很容易地用于临床使用。患牙的术前疼痛持续时间可能与VPT的预后显着相关。
方法：115颗因深层护理引起的可逆性或不可逆性牙髓炎的牙齿随机分为2组。TheraCalLC和iRootBPPlus用于纸浆封盖。直接盖浆(DPC),根据对暴露牙髓的观察，进行部分牙髓切除术（PP）和完全牙髓切除术（FP）。通过随访电话询问并记录了术后不适。术后3、6和12个月进行临床和影像学评估。
结果：两组第一年的总体临床成功率均为90.4％（47/52）。TH组需要较少的操作时间，显示较低的疼痛程度，术后疼痛持续时间较短(P<.001)。根据二元逻辑回归模型，术前疼痛持续时间与VPT预后显著相关(P=.011).
结论：VPT联合TheraCalLC和iRootBPPlus在牙髓炎恒牙龋齿中均取得了良好的临床效果，和TheraCalLC可以很容易地用于临床使用。患牙的术前疼痛持续时间可能与VPT的预后显着相关。
