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Abstract：
BACKGROUND: Dogs with congenital intrahepatic portosystemic shunt (IHPSS) are predisposed to gastrointestinal inflammation, ulceration, and bleeding, unlike dogs with congenital extrahepatic portosystemic shunt (EHPSS). Limited information is available about hematologic differences between dogs with IHPSS and dogs with EHPSS.
OBJECTIVE: Compare hemogram variables between dogs with IHPSS and EHPSS. We hypothesized that hematologic variables would differ between the 2 populations, with a higher frequency and severity of anemia and microcytosis in dogs with IHPSS.
METHODS: Twenty-six client-owned dogs with IHPSS and 35 client-owned dogs with EHPSS.
METHODS: Retrospective cross-sectional study. Dogs were included if a CBC was performed before shunt attenuation. Contingency analysis was performed to determine if the frequency of clinical signs and of hematologic variables below the reference range differed between groups. Hematologic and selected biochemical variables were compared between groups using an analysis of covariance with age as a covariate.
RESULTS: Gastrointestinal clinical signs (IHPSS, 81% vs EHPSS, 34%; P = .01), anemia (31% vs 6%; P = .01), microcytosis (77% vs 29%; P = .002), and hypochromia (77% vs 49%; P = .03) were more common in dogs with IHPSS than in dogs with EHPSS. Dogs with IHPSS had lower packed cell volume (34% vs 41%, P = .04), hemoglobin concentration (11.5 g/dL vs 13.7 g/dL, P = .03), mean corpuscular volume (57 fL vs 65 fL; P = .001), and mean corpuscular hemoglobin concentration (32 g/dL vs 33 g/dL; P = .04) than dogs with EHPSS.
CONCLUSIONS: Dogs with IHPSS had a higher frequency of anemia, microcytosis, and hypochromia and exhibited more gastrointestinal clinical signs.
OBJECTIVE: Compare hemogram variables between dogs with IHPSS and EHPSS. We hypothesized that hematologic variables would differ between the 2 populations, with a higher frequency and severity of anemia and microcytosis in dogs with IHPSS.
METHODS: Twenty-six client-owned dogs with IHPSS and 35 client-owned dogs with EHPSS.
METHODS: Retrospective cross-sectional study. Dogs were included if a CBC was performed before shunt attenuation. Contingency analysis was performed to determine if the frequency of clinical signs and of hematologic variables below the reference range differed between groups. Hematologic and selected biochemical variables were compared between groups using an analysis of covariance with age as a covariate.
RESULTS: Gastrointestinal clinical signs (IHPSS, 81% vs EHPSS, 34%; P = .01), anemia (31% vs 6%; P = .01), microcytosis (77% vs 29%; P = .002), and hypochromia (77% vs 49%; P = .03) were more common in dogs with IHPSS than in dogs with EHPSS. Dogs with IHPSS had lower packed cell volume (34% vs 41%, P = .04), hemoglobin concentration (11.5 g/dL vs 13.7 g/dL, P = .03), mean corpuscular volume (57 fL vs 65 fL; P = .001), and mean corpuscular hemoglobin concentration (32 g/dL vs 33 g/dL; P = .04) than dogs with EHPSS.
CONCLUSIONS: Dogs with IHPSS had a higher frequency of anemia, microcytosis, and hypochromia and exhibited more gastrointestinal clinical signs.
摘要：
背景：患有先天性肝内门体分流术（IHPSS）的狗易患胃肠道炎症，溃疡,流血，与患有先天性肝外门体分流术（EHPSS）的狗不同。关于患有IHPSS的狗和患有EHPSS的狗之间的血液学差异的信息有限。
目的：比较IHPSS和EHPSS犬的血象变量。我们假设两个群体之间的血液学变量会有所不同，在患有IHPSS的狗中，贫血和微细胞增多的频率和严重程度更高。
方法：26只带有IHPSS的客户拥有的狗和35只带有EHPSS的客户拥有的狗。
方法：回顾性横断面研究。如果在分流衰减之前进行CBC,则包括狗。进行应急分析以确定低于参考范围的临床体征和血液学变量的频率是否在组间不同。使用年龄作为协变量的协方差分析，比较了各组之间的血液学和选定的生化变量。
结果：胃肠道临床体征（IHPSS，81%vsEHPSS，34%；P=0.01），贫血（31%vs6%；P=0.01），微细胞增多（77%对29%；P=0.002），与EHPSS的犬相比，IHPSS的犬更常见低铬血症（77％vs49％；P=0.03）。患有IHPSS的狗的细胞体积较低(34%vs41%，P=.04)，血红蛋白浓度（11.5g/dLvs13.7g/dL，P=.03)，平均红细胞体积（57fLvs65fL；P=.001），与EHPSS犬相比，平均红细胞血红蛋白浓度（32g/dLvs33g/dL；P=.04）。
结论：患有IHPSS的狗贫血的频率更高，微胞嘧啶,和低铬和表现出更多的胃肠道临床体征。
目的：比较IHPSS和EHPSS犬的血象变量。我们假设两个群体之间的血液学变量会有所不同，在患有IHPSS的狗中，贫血和微细胞增多的频率和严重程度更高。
方法：26只带有IHPSS的客户拥有的狗和35只带有EHPSS的客户拥有的狗。
方法：回顾性横断面研究。如果在分流衰减之前进行CBC,则包括狗。进行应急分析以确定低于参考范围的临床体征和血液学变量的频率是否在组间不同。使用年龄作为协变量的协方差分析，比较了各组之间的血液学和选定的生化变量。
结果：胃肠道临床体征（IHPSS，81%vsEHPSS，34%；P=0.01），贫血（31%vs6%；P=0.01），微细胞增多（77%对29%；P=0.002），与EHPSS的犬相比，IHPSS的犬更常见低铬血症（77％vs49％；P=0.03）。患有IHPSS的狗的细胞体积较低(34%vs41%，P=.04)，血红蛋白浓度（11.5g/dLvs13.7g/dL，P=.03)，平均红细胞体积（57fLvs65fL；P=.001），与EHPSS犬相比，平均红细胞血红蛋白浓度（32g/dLvs33g/dL；P=.04）。
结论：患有IHPSS的狗贫血的频率更高，微胞嘧啶,和低铬和表现出更多的胃肠道临床体征。
