PDF(Pubmed)
Abstract：
UNASSIGNED: Hepatogenous diabetes (HD) is frequently underestimated among cirrhosis patients. The current study assessed the magnitude, clinical characteristics, and implications of HD in cirrhosis patients as compared to the patients with type-2 diabetes mellitus (T2DM) and non-diabetes (ND) cirrhosis.
UNASSIGNED: In a prospective observational study, 338 consecutive eligible cirrhosis patients were screened for diabetes mellitus. A 2-hour oral glucose tolerance test (OGTT) was used to detect HD. The clinical characteristics, complications, and outcomes were ascertained and compared amongst HD, T2DM, and ND patients.
UNASSIGNED: In the final study cohort of 316 patients, the proportion of HD, T2DM, and ND was 22.5% (n = 71), 26.3% (n = 83), and 51.3% (n = 162), respectively. HD was the predominant form of diabetes (68.9%) in Child-Pugh class-C cirrhosis. The majority (73%) of HD patients had abnormal OGTT without fasting hyperglycaemia. A lower cut-off of 98.5 mg/dl for fasting blood glucose had a modest sensitivity (72%) and specificity (75%) for predicting HD. In comparison to T2DM patients, HD patients were younger, leaner, and had more advanced cirrhosis. In comparison to ND patients, HD patients were leaner but had higher glycemic indices, serum cholesterol, and arterial ammonia levels. During a median follow-up period of 12 (03-21) months, the frequency of hepatic encephalopathy and variceal haemorrhage were higher in HD and T2DM patients compared to that in the ND group.
UNASSIGNED: HD is prevalent in about one fifth of cirrhosis patients. It differs from T2DM and ND in a number of ways, and has association with complications of cirrhosis.
UNASSIGNED: In a prospective observational study, 338 consecutive eligible cirrhosis patients were screened for diabetes mellitus. A 2-hour oral glucose tolerance test (OGTT) was used to detect HD. The clinical characteristics, complications, and outcomes were ascertained and compared amongst HD, T2DM, and ND patients.
UNASSIGNED: In the final study cohort of 316 patients, the proportion of HD, T2DM, and ND was 22.5% (n = 71), 26.3% (n = 83), and 51.3% (n = 162), respectively. HD was the predominant form of diabetes (68.9%) in Child-Pugh class-C cirrhosis. The majority (73%) of HD patients had abnormal OGTT without fasting hyperglycaemia. A lower cut-off of 98.5 mg/dl for fasting blood glucose had a modest sensitivity (72%) and specificity (75%) for predicting HD. In comparison to T2DM patients, HD patients were younger, leaner, and had more advanced cirrhosis. In comparison to ND patients, HD patients were leaner but had higher glycemic indices, serum cholesterol, and arterial ammonia levels. During a median follow-up period of 12 (03-21) months, the frequency of hepatic encephalopathy and variceal haemorrhage were higher in HD and T2DM patients compared to that in the ND group.
UNASSIGNED: HD is prevalent in about one fifth of cirrhosis patients. It differs from T2DM and ND in a number of ways, and has association with complications of cirrhosis.
摘要：
■肝源性糖尿病（HD）在肝硬化患者中经常被低估。目前的研究评估了震级，临床特征,与2型糖尿病（T2DM）和非糖尿病（ND）肝硬化患者相比，肝硬化患者中HD的意义。
■在一项前瞻性观察性研究中，对338例连续符合条件的肝硬化患者进行糖尿病筛查。使用2小时口服葡萄糖耐量试验(OGTT)来检测HD。临床特点,并发症,并在HD之间确定和比较结果，T2DM,ND患者。
■在316名患者的最终研究队列中，HD的比例，T2DM,ND为22.5%(n=71)，26.3%(n=83)，51.3%(n=162)，分别。HD是Child-PughC级肝硬化中糖尿病的主要形式（68.9％）。大多数（73％）HD患者的OGTT异常，无空腹高血糖。空腹血糖的下限为98.5mg/dl，对于预测HD具有适度的敏感性（72％）和特异性（75％）。与T2DM患者相比，HD患者更年轻，leaner,患有更晚期的肝硬化。与ND患者相比，HD患者较瘦，但血糖指数较高，血清胆固醇，和动脉氨水平。在12（03-21）个月的中位随访期内，HD和T2DM患者的肝性脑病和静脉曲张出血发生率高于ND组.
■HD在约五分之一的肝硬化患者中普遍存在。它在许多方面与T2DM和ND不同，并与肝硬化并发症有关。
■在一项前瞻性观察性研究中，对338例连续符合条件的肝硬化患者进行糖尿病筛查。使用2小时口服葡萄糖耐量试验(OGTT)来检测HD。临床特点,并发症,并在HD之间确定和比较结果，T2DM,ND患者。
■在316名患者的最终研究队列中，HD的比例，T2DM,ND为22.5%(n=71)，26.3%(n=83)，51.3%(n=162)，分别。HD是Child-PughC级肝硬化中糖尿病的主要形式（68.9％）。大多数（73％）HD患者的OGTT异常，无空腹高血糖。空腹血糖的下限为98.5mg/dl，对于预测HD具有适度的敏感性（72％）和特异性（75％）。与T2DM患者相比，HD患者更年轻，leaner,患有更晚期的肝硬化。与ND患者相比，HD患者较瘦，但血糖指数较高，血清胆固醇，和动脉氨水平。在12（03-21）个月的中位随访期内，HD和T2DM患者的肝性脑病和静脉曲张出血发生率高于ND组.
■HD在约五分之一的肝硬化患者中普遍存在。它在许多方面与T2DM和ND不同，并与肝硬化并发症有关。
