Abstract：
OBJECTIVE: To evaluate gastric emptying (GE) and the glycaemic response to a 75-g oral glucose load in newly diagnosed, treatment-naïve Han Chinese with type 2 diabetes (T2D) before insulin pump therapy, after 4 weeks of insulin pump therapy, and 12-15 months after insulin pump therapy.
METHODS: Twenty participants with T2D (baseline glycated haemoglobin [± SD] 10.7% [± 1.2%] 93 [± 10] mmol/mol) ingested a 75-g glucose drink containing 150 mg 13C-acetate, to determine the gastric half-emptying time, and underwent assessment of plasma glucose and serum insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over 180 min before and after 4 weeks of insulin pump therapy (discontinued for 48 h before re-assessment). Data were compared to those in 19 healthy participants matched for sex and age. After 12-15 months, GE was re-measured in 14 of the T2D participants.
RESULTS: At baseline, participants with T2D exhibited substantially augmented fasting and post-glucose glycaemia, diminished insulin secretion, and more rapid GE (p < 0.05 each), but comparable GLP-1, compared to healthy participants. Following insulin pump therapy, insulin secretion increased, GLP-1 secretion was attenuated, fasting and post-glucose glycaemia were lower, and GE was slowed (p < 0.05 each). The slowing of GE in T2D participants was sustained over 12-15 months of follow-up.
CONCLUSIONS: In newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short-term insulin pump therapy. The effect on GE is maintained for at least 12 months.
METHODS: Twenty participants with T2D (baseline glycated haemoglobin [± SD] 10.7% [± 1.2%] 93 [± 10] mmol/mol) ingested a 75-g glucose drink containing 150 mg 13C-acetate, to determine the gastric half-emptying time, and underwent assessment of plasma glucose and serum insulin, C-peptide and glucagon-like peptide-1 (GLP-1) over 180 min before and after 4 weeks of insulin pump therapy (discontinued for 48 h before re-assessment). Data were compared to those in 19 healthy participants matched for sex and age. After 12-15 months, GE was re-measured in 14 of the T2D participants.
RESULTS: At baseline, participants with T2D exhibited substantially augmented fasting and post-glucose glycaemia, diminished insulin secretion, and more rapid GE (p < 0.05 each), but comparable GLP-1, compared to healthy participants. Following insulin pump therapy, insulin secretion increased, GLP-1 secretion was attenuated, fasting and post-glucose glycaemia were lower, and GE was slowed (p < 0.05 each). The slowing of GE in T2D participants was sustained over 12-15 months of follow-up.
CONCLUSIONS: In newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short-term insulin pump therapy. The effect on GE is maintained for at least 12 months.
摘要：
目的：评估新诊断患者的胃排空（GE）和对75克口服葡萄糖负荷的血糖反应，胰岛素泵治疗前的初治汉族2型糖尿病（T2D），胰岛素泵治疗4周后，胰岛素泵治疗后12-15个月。
方法：20名患有T2D（基线糖化血红蛋白[±SD]10.7%[±1.2%]93[±10]mmol/mol）的参与者摄入了含有150毫克13C-乙酸盐的75克葡萄糖饮料，确定胃半排空时间,并接受了血浆葡萄糖和血清胰岛素的评估，C肽和胰高血糖素样肽-1（GLP-1）在胰岛素泵治疗4周之前和之后的180分钟内（在重新评估之前中断48小时）。将数据与性别和年龄相匹配的19名健康参与者进行比较。12-15个月后,在14名T2D参与者中重新测量了GE。
结果：在基线时，患有T2D的参与者表现出显著增加的空腹和血糖后，胰岛素分泌减少，和更快的GE（每个p<0.05），但与健康参与者相比，GLP-1相当。胰岛素泵治疗后，胰岛素分泌增加，GLP-1分泌减弱，空腹血糖和血糖后血糖较低，GE减慢（各p<0.05）。T2D参与者的GE减缓持续了12-15个月的随访。
结论：在新诊断的汉族T2D患者中，尽管血糖控制不佳，但GE通常会加速，并且通过短期胰岛素泵治疗会减慢。对GE的作用维持至少12个月。
方法：20名患有T2D（基线糖化血红蛋白[±SD]10.7%[±1.2%]93[±10]mmol/mol）的参与者摄入了含有150毫克13C-乙酸盐的75克葡萄糖饮料，确定胃半排空时间,并接受了血浆葡萄糖和血清胰岛素的评估，C肽和胰高血糖素样肽-1（GLP-1）在胰岛素泵治疗4周之前和之后的180分钟内（在重新评估之前中断48小时）。将数据与性别和年龄相匹配的19名健康参与者进行比较。12-15个月后,在14名T2D参与者中重新测量了GE。
结果：在基线时，患有T2D的参与者表现出显著增加的空腹和血糖后，胰岛素分泌减少，和更快的GE（每个p<0.05），但与健康参与者相比，GLP-1相当。胰岛素泵治疗后，胰岛素分泌增加，GLP-1分泌减弱，空腹血糖和血糖后血糖较低，GE减慢（各p<0.05）。T2D参与者的GE减缓持续了12-15个月的随访。
结论：在新诊断的汉族T2D患者中，尽管血糖控制不佳，但GE通常会加速，并且通过短期胰岛素泵治疗会减慢。对GE的作用维持至少12个月。
