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Abstract：
BACKGROUND: Multidrug-resistant tuberculosis is a type of tuberculosis that is resistant to at least the first-line antituberculosis drugs namely, rifampicin and isoniazid. However, most of these studies were limited only to a single hospital. Therefore, this study aimed to identify the determinants of multidrug-resistant tuberculosis among adults undergoing treatment for tuberculosis in the Tigray region of Ethiopia.
METHODS: Hospital-based unmatched case-control study was conducted from 1 April 2019 to 30 June 2019. A simple random sampling method was used to select the required sample size. Variables at a p value less than 0.25 in bivariate analysis were entered into a multivariable analysis to identify the determinant factors of multidrug-resistant tuberculosis. Finally, the level of significance was declared at p<0.05.
RESULTS: Rural residence (adjusted OR (AOR) 2.54; 95% CI 1.34 to 4.83), HIV (AOR 4.5; 95% CI 1.4 to 14.2), relapse (AOR 3.86; 95% CI 1.98 to 7.5), return after lost follow-up (AOR 6.29; 95% CI 1.64 to 24.2), treatment failure (AOR 5.87; 95% CI 1.39 to 24.8) were among the determinants of multidrug-resistant tuberculosis.
CONCLUSIONS: Rural residence, HIV, relapses, return after lost follow-up and treatment failure were the identified determinant factors of multidrug-resistance tuberculosis.
METHODS: Hospital-based unmatched case-control study was conducted from 1 April 2019 to 30 June 2019. A simple random sampling method was used to select the required sample size. Variables at a p value less than 0.25 in bivariate analysis were entered into a multivariable analysis to identify the determinant factors of multidrug-resistant tuberculosis. Finally, the level of significance was declared at p<0.05.
RESULTS: Rural residence (adjusted OR (AOR) 2.54; 95% CI 1.34 to 4.83), HIV (AOR 4.5; 95% CI 1.4 to 14.2), relapse (AOR 3.86; 95% CI 1.98 to 7.5), return after lost follow-up (AOR 6.29; 95% CI 1.64 to 24.2), treatment failure (AOR 5.87; 95% CI 1.39 to 24.8) were among the determinants of multidrug-resistant tuberculosis.
CONCLUSIONS: Rural residence, HIV, relapses, return after lost follow-up and treatment failure were the identified determinant factors of multidrug-resistance tuberculosis.
摘要：
背景：耐多药结核病是一种对至少一线抗结核药物具有抗性的结核病，即，利福平和异烟肼.然而,这些研究大多仅限于一家医院.因此,本研究旨在确定埃塞俄比亚提格雷地区接受结核病治疗的成人耐多药结核病的决定因素.
方法：以医院为基础的无匹配病例对照研究于2019年4月1日至2019年6月30日进行。使用简单随机抽样方法来选择所需的样本量。将双变量分析中p值小于0.25的变量输入多变量分析，以确定耐多药结核病的决定因素。最后,显著性水平为p<0.05。
结果：农村住宅（调整后OR（AOR）2.54；95%CI1.34至4.83），HIV（AOR4.5；95%CI1.4至14.2），复发（AOR3.86；95%CI1.98至7.5），失去随访后的回报(AOR6.29；95%CI1.64至24.2)，治疗失败(AOR5.87;95%CI1.39~24.8)是耐多药结核病的决定因素之一.
结论：农村住宅，艾滋病毒,复发,失访后复发和治疗失败是确定的耐多药结核病的决定因素.
方法：以医院为基础的无匹配病例对照研究于2019年4月1日至2019年6月30日进行。使用简单随机抽样方法来选择所需的样本量。将双变量分析中p值小于0.25的变量输入多变量分析，以确定耐多药结核病的决定因素。最后,显著性水平为p<0.05。
结果：农村住宅（调整后OR（AOR）2.54；95%CI1.34至4.83），HIV（AOR4.5；95%CI1.4至14.2），复发（AOR3.86；95%CI1.98至7.5），失去随访后的回报(AOR6.29；95%CI1.64至24.2)，治疗失败(AOR5.87;95%CI1.39~24.8)是耐多药结核病的决定因素之一.
结论：农村住宅，艾滋病毒,复发,失访后复发和治疗失败是确定的耐多药结核病的决定因素.
