NRDE2 缺乏损害同源重组修复并使肝细胞癌对 PARP 抑制剂敏感。
关键词: NRDE2 PARP inhibitors hepatocellular carcinoma homologous recombination repair rare variant
Mesh : Animals Female Humans Male Mice Middle Aged Carcinoma, Hepatocellular / drug therapy genetics pathology Casein Kinase II / genetics metabolism Cell Line, Tumor Genetic Predisposition to Disease Liver Neoplasms / drug therapy genetics pathology Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use pharmacology Recombinational DNA Repair / drug effects Mice, Nude Mice, Inbred BALB C Adult
来 源:
DOI:10.1016/j.xgen.2024.100550
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