PDF(Pubmed)
Abstract：
UNASSIGNED: Safe removal of extensive liver tumor burdens depends on regeneration of the remnant liver, which requires a large amount of zinc over a short period of time. We studied how zinc influences regeneration.
UNASSIGNED: We measured perioperative serum zinc concentrations after liver cancer diagnosis in 77 patients undergoing hepatectomy to determine how serum zinc affected short-term outcomes and remnant liver regeneration.
UNASSIGNED: Serum zinc concentration at diagnosis showed no correlation with inflammatory or nutritional parameters except for a weak correlation with the lymphocyte-to-monocyte ratio. When patients were divided into a high pre-hepatectomy zinc group (≥75 µg/dL, n= 39, H group) and a low zinc group (<75 µg/dL, n= 38, L group), short-term results such as mortality (p> 0.999), morbidity (p= 0.490), and hospital stay (p= 0.591) did not differ between groups. However, hypertrophy in the future liver remnant after hepatectomy in the H group (127.7 ± 24.7% of original volume) was greater than in the L group (115.9 ± 16.7%, p= 0.024). In a subgroup of patients with extended hepatectomy, hypertrophy was 130.9 ± 26.8% in the H group vs. 116.4 ± 16.5% in the L group (p= 0.037).
UNASSIGNED: Greater serum zinc at diagnosis was associated with greater hypertrophy in the future liver remnant.
UNASSIGNED: We measured perioperative serum zinc concentrations after liver cancer diagnosis in 77 patients undergoing hepatectomy to determine how serum zinc affected short-term outcomes and remnant liver regeneration.
UNASSIGNED: Serum zinc concentration at diagnosis showed no correlation with inflammatory or nutritional parameters except for a weak correlation with the lymphocyte-to-monocyte ratio. When patients were divided into a high pre-hepatectomy zinc group (≥75 µg/dL, n= 39, H group) and a low zinc group (<75 µg/dL, n= 38, L group), short-term results such as mortality (p> 0.999), morbidity (p= 0.490), and hospital stay (p= 0.591) did not differ between groups. However, hypertrophy in the future liver remnant after hepatectomy in the H group (127.7 ± 24.7% of original volume) was greater than in the L group (115.9 ± 16.7%, p= 0.024). In a subgroup of patients with extended hepatectomy, hypertrophy was 130.9 ± 26.8% in the H group vs. 116.4 ± 16.5% in the L group (p= 0.037).
UNASSIGNED: Greater serum zinc at diagnosis was associated with greater hypertrophy in the future liver remnant.
摘要：
■广泛的肝肿瘤负荷的安全去除取决于残余肝脏的再生，这需要在短时间内大量的锌。我们研究了锌如何影响再生。
■我们测量了77例接受肝切除术的肝癌诊断患者围手术期血清锌浓度，以确定血清锌如何影响短期预后和残余肝再生。
■诊断时的血清锌浓度与炎症或营养参数无相关性，但与淋巴细胞与单核细胞比率的相关性较弱。当患者被分为高肝切除术前锌组（≥75µg/dL，n=39，H组）和低锌组（<75µg/dL，n=38，L组），短期结果，如死亡率(p>0.999)，发病率（p=0.490），两组间住院时间(p=0.591)无差异.然而,H组肝切除术后剩余肝肥大（占原始体积的127.7±24.7％）大于L组（115.9±16.7％，p=0.024)。在扩大肝切除术的患者亚组中，H组肥大为130.9±26.8%L组116.4±16.5%(p=0.037)。
■诊断时更高的血清锌与未来肝脏残留的更大的肥大相关。
■我们测量了77例接受肝切除术的肝癌诊断患者围手术期血清锌浓度，以确定血清锌如何影响短期预后和残余肝再生。
■诊断时的血清锌浓度与炎症或营养参数无相关性，但与淋巴细胞与单核细胞比率的相关性较弱。当患者被分为高肝切除术前锌组（≥75µg/dL，n=39，H组）和低锌组（<75µg/dL，n=38，L组），短期结果，如死亡率(p>0.999)，发病率（p=0.490），两组间住院时间(p=0.591)无差异.然而,H组肝切除术后剩余肝肥大（占原始体积的127.7±24.7％）大于L组（115.9±16.7％，p=0.024)。在扩大肝切除术的患者亚组中，H组肥大为130.9±26.8%L组116.4±16.5%(p=0.037)。
■诊断时更高的血清锌与未来肝脏残留的更大的肥大相关。
