PDF(Pubmed)
Abstract：
Preimplantation genetic testing (PGT) has become an integral component of assisted reproductive technology (ART), offering couples the opportunity to screen embryos for genetic abnormalities before implantation during in vitro fertilization (IVF). This comprehensive review explores the advancements and applications of PGT in IVF, covering its various types, technological developments, clinical applications, efficacy, challenges, regulatory aspects, and future directions. The evolution of PGT techniques, including next-generation sequencing (NGS) and comparative genomic hybridization (CGH), has significantly enhanced the accuracy and reliability of genetic testing in embryos. PGT holds profound implications for the future of ART by improving IVF success rates, reducing the incidence of genetic disorders, and mitigating the emotional and financial burdens associated with failed pregnancies and genetic diseases. Recommendations for clinicians, researchers, and policymakers include staying updated on the latest PGT techniques and guidelines, exploring innovative technologies, establishing clear regulatory frameworks, and fostering collaboration to maximize the potential benefits of PGT in assisted reproduction. Overall, this review provides valuable insights into the current state of PGT and its implications for the field of reproductive medicine.
摘要：
植入前基因检测（PGT）已成为辅助生殖技术（ART）不可或缺的组成部分，在体外受精（IVF）期间，为夫妇提供在植入胚胎之前筛查遗传异常的机会。这篇全面的综述探讨了PGT在IVF中的进展和应用，涵盖其各种类型，技术发展,临床应用，功效,挑战,监管方面，和未来的方向。PGT技术的发展，包括下一代测序（NGS）和比较基因组杂交（CGH），大大提高了胚胎基因检测的准确性和可靠性。PGT通过提高IVF成功率对ART的未来具有深远的意义，减少遗传性疾病的发病率，减轻与怀孕失败和遗传疾病相关的情感和经济负担。对临床医生的建议，研究人员,政策制定者包括保持最新的PGT技术和指南，探索创新技术，建立明确的监管框架，并促进合作，以最大限度地提高PGT在辅助生殖中的潜在利益。总的来说,这篇综述为PGT的现状及其对生殖医学领域的影响提供了有价值的见解。
