PDF(Pubmed)
Abstract：
UNASSIGNED: In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis.
UNASSIGNED: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed.
UNASSIGNED: Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival.
UNASSIGNED: Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies.
UNASSIGNED: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed.
UNASSIGNED: Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival.
UNASSIGNED: Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies.
摘要：
■在局部晚期直肠癌（LARC）中，肿瘤淋巴结转移（TNM）分期远非最佳。作者旨在研究先前描述的循环生物标志物作为预后预测因子的价值。
■对2010年1月至2022年12月诊断的245例LARC患者进行回顾性分析，这些患者在两个中心接受了新辅助放化疗和手术。进行Cox回归和Kaplan-Meier分析。
■治疗后血小板与淋巴细胞比率(PLR)预测病理完全缓解。治疗的两个时间点的中性粒细胞与淋巴细胞比率（NLR）显着预测总生存期，而血小板-中性粒细胞（PN）指数可显着预测无病生存率。在病理II期，PN指数预测患者无病生存风险较高.
■血液参数可能允许对TNM以外的风险亚组进行定义，以应用不同的治疗策略。
■对2010年1月至2022年12月诊断的245例LARC患者进行回顾性分析，这些患者在两个中心接受了新辅助放化疗和手术。进行Cox回归和Kaplan-Meier分析。
■治疗后血小板与淋巴细胞比率(PLR)预测病理完全缓解。治疗的两个时间点的中性粒细胞与淋巴细胞比率（NLR）显着预测总生存期，而血小板-中性粒细胞（PN）指数可显着预测无病生存率。在病理II期，PN指数预测患者无病生存风险较高.
■血液参数可能允许对TNM以外的风险亚组进行定义，以应用不同的治疗策略。
