%0 Journal Article
%T Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-neutrophil (PN) index in locally advanced rectal cancer patients: a retrospective cohort study.
%A Morais M
%A Fonseca T
%A Machado-Neves R
%A Honavar M
%A Coelho AR
%A Lopes J
%A Guerreiro E
%A Carneiro S
%J Ann Med Surg (Lond)
%V 86
%N 5
%D 2024 May
%M 38694305
暂无%R 10.1097/MS9.0000000000001297
%X <B>UNASSIGNED: </B>In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis.<BR><B>UNASSIGNED: </B>Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed.<BR><B>UNASSIGNED: </B>Post-treatment platelet-to-lymphocyte ratio (PLR) predicted pathological complete response. The neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas the platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, the PN index predicted patients with a higher risk of disease-free survival.<BR><B>UNASSIGNED: </B>Blood parameters might allow the definition of subgroups of risk beyond TNM for the application of different therapeutic strategies.