This article reports a case of a patient with hormone receptor-positive, HER2-negative breast invasive lobular carcinoma with gastrointestinal tract and skin metastases. The patient was assessed by a second-look ultrasound and diagnosed by subsequent ultrasound-guided needle biopsy. Following endocrine therapy, a favorable effect was observed, with significant regression of the primary breast lesion, cutaneous metastases, and gastrointestinal metastases.
Patients with breast invasive lobular carcinoma should be alert to the possibility of breast cancer metastasis, even if there are no obvious symptoms or signs, when they encounter rapidly progressive cutaneous nodules or plaques, or if they possess gastrointestinal abnormalities. For patients with negative breast ultrasonography for the first time, after combining mammography, Contrast-enhanced Spectral Mammography (CESM) or Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) examinations, if breast cancer is highly suspected, second-look ultrasound is particularly crucial at this juncture, which is the key prerequisite for breast needle biopsy and obtaining the gold standard of pathology.
方法:本文报道一例激素受体阳性患者,HER2阴性乳腺浸润性小叶癌合并胃肠道和皮肤转移。通过二次超声评估患者,并通过随后的超声引导穿刺活检进行诊断。内分泌治疗后,观察到了良好的效果,随着原发性乳腺病变的显著消退,皮肤转移瘤,和胃肠道转移。
结论:乳腺浸润性小叶癌患者应警惕乳腺癌转移的可能性,即使没有明显的症状或体征,当他们遇到快速进展的皮肤结节或斑块时,或者他们有胃肠道异常。首次乳腺超声检查阴性的患者,结合乳房X线照相术后,对比增强光谱乳房X线摄影(CESM)或计算机断层扫描(CT)和磁共振成像(MRI)检查,如果高度怀疑乳腺癌,在这个关头,二次超声尤其重要,这是乳腺针吸活检和获得病理金标准的关键前提。